| Date | Week | Home | Score | Away | Score | |
| 8/17/2018 | 1 | Saint Francis (NC) | 49 | Milwaukee Vincent/Destiny | 0 | |
| 8/24/2018 | 2 | Milwaukee Vincent/Destiny | 26 | Obama SCTE | 0 | |
| 8/31/2018 | 3 | Milwaukee Madison | 0 | Milwaukee Vincent/Destiny | 58 | |
| 9/8/2018 | 4 | Milwaukee Vincent/Destiny | 6 | Milwaukee Reagan | 8 | |
| 9/14/2018 | 5 | Milwaukee Pulaski/Arts/Carmen South/Carmen SE | 3 | Milwaukee Vincent/Destiny | 32 | |
| 9/21/2018 | 6 | Milwaukee Vincent/Destiny | 46 | Milwaukee North | 0 | |
| 9/28/2018 | 7 | Milwaukee South | 28 | Milwaukee Vincent/Destiny | 32 | |
| 10/5/2018 | 8 | Milwaukee Marshall/Carmen Northwest/Juneau/Languages (NC) | 30 | Milwaukee Vincent/Destiny | 14 | |
| 10/11/2018 | 9 | Milwaukee Vincent/Destiny | 36 | Milwaukee King (NC) | 0 | |