| Date | Week | Home | Score | Away | Score | |
| 8/19/2021 | 1 | Spencer/Columbus Catholic | 51 | Glenwood City (NC) | 28 | |
| 8/28/2021 | 2 | Colby (NC) | 38 | Spencer/Columbus Catholic | 0 | |
| 9/3/2021 | 3 | Wittenberg-Birnamwood | 40 | Spencer/Columbus Catholic | 0 | |
| 9/10/2021 | 4 | Weyauwega-Fremont | 28 | Spencer/Columbus Catholic | 48 | |
| 9/17/2021 | 5 | Spencer/Columbus Catholic | 14 | Amherst | 36 | |
| 9/24/2021 | 6 | *Spencer/Columbus Catholic | 28 | *Bangor (NC) | 27 | |
| 9/24/2021 | 6 | Spencer/Columbus Catholic | 1 | Nekoosa | 0 | |
| 10/1/2021 | 7 | Spencer/Columbus Catholic | 36 | Manawa | 8 | |
| 10/8/2021 | 8 | Stratford | 1 | Spencer/Columbus Catholic | 0 | |
| 10/15/2021 | 9 | Spencer/Columbus Catholic | 17 | Shiocton | 6 | |