| Date | Week | Home | Score | Away | Score | |
| 8/21/2021 | 1 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 0 | Racine Horlick (NC) | 55 | |
| 8/27/2021 | 2 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 19 | Milwaukee Bay View/Milw Lifelong Learning | 7 | |
| 9/2/2021 | 3 | Milwaukee King | 1 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 0 | |
| 9/16/2021 | 5 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 39 | Milwaukee Hamilton/Audubon Tech | 0 | |
| 9/23/2021 | 6 | *Milwaukee Reagan (NC) | 6 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 50 | |
| 9/30/2021 | 7 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 26 | Milwaukee Riverside/Golda Meir | 6 | |
| 10/8/2021 | 8 | Milwaukee Bradley Tech/Milw Arts | 0 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 68 | |
| 10/15/2021 | 9 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 21 | Milwaukee King | 19 | |