Central Wisconsin - Large
| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Amherst | 42 | St. Croix Falls (NC) | 19 | |
| 8/27/2021 | 2 | Medford (NC) | 14 | Amherst | 29 | |
| 9/3/2021 | 3 | Shiocton | 7 | Amherst | 47 | |
| 9/10/2021 | 4 | Amherst | 26 | Wittenberg-Birnamwood | 19 | |
| 9/17/2021 | 5 | Spencer/Columbus Catholic | 14 | Amherst | 36 | |
| 9/24/2021 | 6 | *Markesan (NC) | 15 | *Amherst | 29 | |
| 9/24/2021 | 6 | Amherst | 1 | Weyauwega-Fremont | 0 | |
| 10/1/2021 | 7 | Nekoosa | 8 | Amherst | 56 | |
| 10/8/2021 | 8 | Amherst | 46 | Manawa | 6 | |
| 10/15/2021 | 9 | Amherst | 28 | Stratford | 14 | |
* Denotes the game does not count towards playoff calculation for the team (exhibition only)