Valley Football Association-West
| Date | Week | Home | Score | Away | Score | |
| 8/19/2021 | 1 | Manitowoc Lincoln (NC) | 12 | Appleton West | 14 | |
| 8/27/2021 | 2 | Appleton West | 30 | Appleton East (NC) | 14 | |
| 9/3/2021 | 3 | Stevens Point Area Senior High | 41 | Appleton West | 6 | |
| 9/10/2021 | 4 | Appleton West | 10 | D.C. Everest | 35 | |
| 9/17/2021 | 5 | Appleton West | 23 | Hortonville | 21 | |
| 9/24/2021 | 6 | Wausau East | 0 | Appleton West | 1 | |
| 9/24/2021 | 6 | *Menomonee Falls (NC) | 14 | *Appleton West | 20 | 1OT |
| 10/1/2021 | 7 | Appleton West | 0 | Marshfield | 21 | |
| 10/8/2021 | 8 | Wausau West | 42 | Appleton West | 6 | |
| 10/15/2021 | 9 | Appleton West | 17 | Wisconsin Rapids Lincoln | 31 | |
* Denotes the game does not count towards playoff calculation for the team (exhibition only)