| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Hilbert (NC) | 14 | Brillion | 0 | |
| 8/27/2021 | 2 | Brillion | 33 | Weyauwega-Fremont (NC) | 0 | |
| 9/3/2021 | 3 | Brillion | 41 | Two Rivers | 0 | |
| 9/11/2021 | 4 | Brillion | 42 | Valders | 0 | |
| 9/17/2021 | 5 | Kiel | 0 | Brillion | 21 | |
| 9/24/2021 | 6 | New Holstein | 7 | Brillion | 10 | |
| 10/1/2021 | 7 | Roncalli | 0 | Brillion | 42 | |
| 10/8/2021 | 8 | Brillion | 34 | Chilton | 7 | |
| 10/15/2021 | 9 | Kohler/Sheboygan Christian/Sheboygan Lutheran | 18 | Brillion | 21 | |