| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Catholic Memorial (NC) | 29 | Brookfield Central | 27 | |
| 8/27/2021 | 2 | Brookfield Central | 25 | Pulaski (NC) | 30 | |
| 9/3/2021 | 3 | Brookfield Central | 14 | West Allis Hale | 21 | |
| 9/10/2021 | 4 | West Allis Central | 0 | Brookfield Central | 1 | |
| 9/10/2021 | 4 | *Kenosha Indian Trail (NC) | 6 | *Brookfield Central | 42 | |
| 9/17/2021 | 5 | Brookfield East | 21 | Brookfield Central | 7 | |
| 9/24/2021 | 6 | Brookfield Central | 41 | Marquette | 38 | 1OT |
| 10/1/2021 | 7 | Hamilton | 41 | Brookfield Central | 14 | |
| 10/8/2021 | 8 | Germantown | 21 | Brookfield Central | 3 | |
| 10/15/2021 | 9 | Brookfield Central | 42 | Menomonee Falls | 28 | |