| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | New Glarus/Monticello (NC) | 26 | Clinton | 27 | |
| 8/27/2021 | 2 | Clinton | 16 | Edgerton (NC) | 13 | |
| 9/3/2021 | 3 | Dodgeland | 6 | Clinton | 55 | |
| 9/10/2021 | 4 | Marshall | 28 | Clinton | 6 | |
| 9/17/2021 | 5 | Pardeeville | 1 | Clinton | 0 | |
| 9/24/2021 | 6 | Markesan | 1 | Clinton | 0 | |
| 10/1/2021 | 7 | Clinton | 56 | Palmyra-Eagle | 6 | |
| 10/8/2021 | 8 | Clinton | 18 | Waterloo | 33 | |
| 10/15/2021 | 9 | Cambridge | 6 | Clinton | 48 | |