| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Neillsville/Granton (NC) | 0 | Colby | 37 | |
| 8/28/2021 | 2 | Colby | 38 | Spencer/Columbus Catholic (NC) | 0 | |
| 9/3/2021 | 3 | *Southern Door (NC) | 7 | *Colby | 52 | |
| 9/3/2021 | 3 | Athens | 0 | Colby | 1 | |
| 9/10/2021 | 4 | Colby | 29 | Edgar | 14 | |
| 9/17/2021 | 5 | Abbotsford | 0 | Colby | 1 | |
| 9/24/2021 | 6 | Thorp | 0 | Colby | 1 | |
| 10/1/2021 | 7 | *Hortonville (NC) | 19 | *Colby | 13 | |
| 10/1/2021 | 7 | Marathon | 0 | Colby | 42 | |
| 10/8/2021 | 8 | Owen-Withee | 0 | Colby | 1 | |
| 10/8/2021 | 8 | *Colby | 62 | *Ladysmith (NC) | 6 | |
| 10/15/2021 | 9 | Colby | 54 | Auburndale | 7 | |