| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Fennimore (NC) | 47 | Iowa-Grant | 0 | |
| 8/27/2021 | 2 | Iowa-Grant | 26 | Riverdale (NC) | 14 | |
| 9/3/2021 | 3 | Black Hawk/Warren, IL | 56 | Iowa-Grant | 0 | |
| 9/10/2021 | 4 | Southwestern/East Dubuque, IL | 28 | Iowa-Grant | 12 | |
| 9/17/2021 | 5 | Iowa-Grant | 6 | Potosi/Cassville | 51 | |
| 9/24/2021 | 6 | Iowa-Grant | 18 | Benton/Scales Mound IL/Shullsburg | 46 | |
| 10/1/2021 | 7 | River Ridge | 1 | Iowa-Grant | 0 | |
| 10/8/2021 | 8 | Parkview/Albany | 28 | Iowa-Grant | 56 | |
| 10/15/2021 | 9 | *Fall Creek (NC) | 19 | *Iowa-Grant | 18 | |
| 10/15/2021 | 9 | Iowa-Grant | 1 | Pecatonica/Argyle | 0 | |