Southwest Wisconsin Activities
| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Arcadia (NC) | 22 | Lancaster | 6 | |
| 8/27/2021 | 2 | River Valley (NC) | 32 | Lancaster | 8 | |
| 9/3/2021 | 3 | Parkview/Albany | 0 | Lancaster | 56 | |
| 9/10/2021 | 4 | Lancaster | 46 | Fennimore | 19 | |
| 9/17/2021 | 5 | Belleville | 28 | Lancaster | 16 | |
| 9/24/2021 | 6 | Lancaster | 38 | Mineral Point | 33 | |
| 10/1/2021 | 7 | Lancaster | 1 | Southwestern/East Dubuque, IL | 0 | |
| 10/1/2021 | 7 | *Lancaster | 21 | *River Ridge (NC) | 26 | |
| 10/8/2021 | 8 | Lancaster | 20 | Cuba City | 28 | |
| 10/15/2021 | 9 | Darlington | 46 | Lancaster | 26 | |
* Denotes the game does not count towards playoff calculation for the team (exhibition only)