| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Horicon/Hustisford (NC) | 27 | Lomira | 42 | |
| 8/27/2021 | 2 | Lomira | 15 | Oostburg (NC) | 17 | |
| 9/3/2021 | 3 | Lomira | 0 | Campbellsport | 30 | |
| 9/11/2021 | 4 | St. Mary's Springs | 28 | Lomira | 6 | |
| 9/17/2021 | 5 | Lomira | 55 | North Fond du Lac | 18 | |
| 9/24/2021 | 6 | Omro | 0 | Lomira | 20 | |
| 10/1/2021 | 7 | Lomira | 7 | Mayville | 42 | |
| 10/8/2021 | 8 | Lomira | 14 | Laconia | 8 | |
| 10/15/2021 | 9 | Winnebago Lutheran Academy | 21 | Lomira | 14 | |