| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Cedar Grove-Belgium (NC) | 38 | Mayville | 20 | |
| 8/27/2021 | 2 | Mayville | 42 | Horicon/Hustisford (NC) | 0 | |
| 9/3/2021 | 3 | Mayville | 35 | St. Mary's Springs | 28 | |
| 9/10/2021 | 4 | North Fond du Lac | 0 | Mayville | 66 | |
| 9/17/2021 | 5 | Mayville | 42 | Omro | 11 | |
| 9/24/2021 | 6 | Laconia | 6 | Mayville | 32 | |
| 10/1/2021 | 7 | Lomira | 7 | Mayville | 42 | |
| 10/8/2021 | 8 | Mayville | 56 | Winnebago Lutheran Academy | 14 | |
| 10/15/2021 | 9 | Campbellsport | 18 | Mayville | 13 | |