| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Waterford (NC) | 42 | Milwaukee King | 12 | |
| 8/27/2021 | 2 | Milwaukee King | 24 | Kenosha Tremper (NC) | 26 | 1OT |
| 9/2/2021 | 3 | Milwaukee King | 1 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 0 | |
| 9/10/2021 | 4 | Milwaukee Hamilton/Audubon Tech | 6 | Milwaukee King | 25 | |
| 9/16/2021 | 5 | *Milwaukee King | 38 | Milwaukee Reagan (NC) | 8 | |
| 9/17/2021 | 5 | Milwaukee King | 1 | Milwaukee Washington/Fuller Collegiate | 0 | |
| 9/24/2021 | 6 | Milwaukee Riverside/Golda Meir | 6 | Milwaukee King | 17 | |
| 9/30/2021 | 7 | Milwaukee King | 55 | Milwaukee Bradley Tech/Milw Arts | 0 | |
| 10/8/2021 | 8 | Milwaukee Bay View/Milw Lifelong Learning | 0 | Milwaukee King | 55 | |
| 10/15/2021 | 9 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 21 | Milwaukee King | 19 | |