| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Mosinee | 7 | Stratford (NC) | 14 | |
| 8/27/2021 | 2 | Mosinee | 30 | Racine Saint Catherine’s (NC) | 12 | |
| 9/3/2021 | 3 | Hayward/Lac Courte Oreilles | 7 | Mosinee | 47 | |
| 9/10/2021 | 4 | Merrill | 0 | Mosinee | 46 | |
| 9/17/2021 | 5 | Mosinee | 1 | Ashland | 0 | |
| 9/17/2021 | 5 | *Mosinee | 40 | *Wittenberg-Birnamwood (NC) | 14 | |
| 9/24/2021 | 6 | Lakeland | 12 | Mosinee | 27 | |
| 10/1/2021 | 7 | Mosinee | 14 | Rhinelander | 7 | |
| 10/8/2021 | 8 | Medford | 14 | Mosinee | 41 | |
| 10/15/2021 | 9 | Mosinee | 1 | Antigo | 0 | |