| Date | Week | Home | Score | Away | Score | |
| 8/19/2021 | 1 | Wisconsin Rapids Lincoln (NC) | 7 | Muskego | 21 | |
| 8/26/2021 | 2 | Muskego | 52 | Kenosha Bradford/Kenosha Reuther (NC) | 14 | |
| 9/3/2021 | 3 | Waukesha South | 14 | Muskego | 58 | |
| 9/10/2021 | 4 | Muskego | 20 | Mukwonago | 14 | |
| 9/17/2021 | 5 | Oconomowoc | 21 | Muskego | 14 | |
| 9/24/2021 | 6 | Muskego | 53 | Arrowhead | 49 | |
| 10/1/2021 | 7 | Waukesha West | 14 | Muskego | 42 | |
| 10/8/2021 | 8 | Muskego | 24 | Kettle Moraine | 0 | |
| 10/15/2021 | 9 | Waukesha North | 7 | Muskego | 56 | |