| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Omro | 0 | Columbus (NC) | 34 | |
| 8/27/2021 | 2 | Winneconne (NC) | 20 | Omro | 19 | |
| 9/3/2021 | 3 | Laconia | 26 | Omro | 7 | |
| 9/10/2021 | 4 | Omro | 14 | Winnebago Lutheran Academy | 21 | |
| 9/17/2021 | 5 | Mayville | 42 | Omro | 11 | |
| 9/24/2021 | 6 | Omro | 0 | Lomira | 20 | |
| 10/1/2021 | 7 | Campbellsport | 1 | Omro | 0 | |
| 10/9/2021 | 8 | St. Mary's Springs | 49 | Omro | 7 | |
| 10/15/2021 | 9 | Omro | 63 | North Fond du Lac | 6 | |