| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Ozaukee | 13 | Kohler/Sheboygan Christian/Sheboygan Lutheran (NC) | 34 | |
| 8/27/2021 | 2 | Ozaukee | 0 | Southern Door (NC) | 27 | |
| 9/2/2021 | 3 | Ozaukee | 7 | Hilbert | 42 | |
| 9/10/2021 | 4 | Reedsville | 48 | Ozaukee | 7 | |
| 9/17/2021 | 5 | Ozaukee | 15 | Manitowoc Lutheran | 14 | |
| 9/24/2021 | 6 | Cedar Grove-Belgium | 50 | Ozaukee | 38 | |
| 10/1/2021 | 7 | Ozaukee | 64 | Random Lake | 6 | |
| 10/8/2021 | 8 | Oostburg | 23 | Ozaukee | 27 | |
| 10/15/2021 | 9 | Ozaukee | 31 | Howards Grove | 22 | |