| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Highland (NC) | 34 | River Ridge | 12 | |
| 8/27/2021 | 2 | River Ridge | 39 | Wauzeka-Steuben/Seneca (NC) | 0 | |
| 9/3/2021 | 3 | Benton/Scales Mound IL/Shullsburg | 12 | River Ridge | 29 | |
| 9/10/2021 | 4 | Pecatonica/Argyle | 8 | River Ridge | 46 | |
| 9/17/2021 | 5 | River Ridge | 41 | Southwestern/East Dubuque, IL | 3 | |
| 9/24/2021 | 6 | Cuba City | 21 | River Ridge | 32 | |
| 10/1/2021 | 7 | River Ridge | 1 | Iowa-Grant | 0 | |
| 10/1/2021 | 7 | *Lancaster (NC) | 21 | *River Ridge | 26 | |
| 10/8/2021 | 8 | Potosi/Cassville | 30 | River Ridge | 26 | |
| 10/15/2021 | 9 | Black Hawk/Warren, IL | 0 | River Ridge | 25 | |