| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Manitowoc Lutheran (NC) | 38 | Roncalli | 26 | |
| 8/27/2021 | 2 | Oconto (NC) | 27 | Roncalli | 0 | |
| 9/3/2021 | 3 | Roncalli | 8 | New Holstein | 36 | |
| 9/10/2021 | 4 | Kohler/Sheboygan Christian/Sheboygan Lutheran | 64 | Roncalli | 0 | |
| 9/17/2021 | 5 | Roncalli | 6 | Valders | 37 | |
| 9/24/2021 | 6 | Chilton | 45 | Roncalli | 8 | |
| 10/1/2021 | 7 | Roncalli | 0 | Brillion | 42 | |
| 10/8/2021 | 8 | Two Rivers | 52 | Roncalli | 0 | |
| 10/15/2021 | 9 | Roncalli | 8 | Kiel | 56 | |