Central Wisconsin - Large
| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Shiocton | 20 | Bonduel (NC) | 6 | |
| 8/26/2021 | 2 | Crivitz (NC) | 14 | Shiocton | 20 | |
| 9/3/2021 | 3 | Shiocton | 7 | Amherst | 47 | |
| 9/10/2021 | 4 | Stratford | 31 | Shiocton | 6 | |
| 9/17/2021 | 5 | *Shiocton | 27 | *Pardeeville (NC) | 0 | |
| 9/17/2021 | 5 | Shiocton | 1 | Weyauwega-Fremont | 0 | |
| 9/24/2021 | 6 | Shiocton | 7 | Manawa | 12 | |
| 10/1/2021 | 7 | Wittenberg-Birnamwood | 51 | Shiocton | 19 | |
| 10/8/2021 | 8 | Shiocton | 34 | Nekoosa | 6 | |
| 10/15/2021 | 9 | Spencer/Columbus Catholic | 17 | Shiocton | 6 | |
* Denotes the game does not count towards playoff calculation for the team (exhibition only)