| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Prescott (NC) | 33 | Spooner | 0 | |
| 8/27/2021 | 2 | Spooner | 31 | Hayward/Lac Courte Oreilles (NC) | 8 | |
| 9/3/2021 | 3 | Spooner | 6 | Northwestern | 21 | |
| 9/10/2021 | 4 | Cumberland | 46 | Spooner | 24 | |
| 9/17/2021 | 5 | St. Croix Falls | 35 | Spooner | 28 | |
| 9/24/2021 | 6 | Spooner | 34 | Barron | 0 | |
| 10/1/2021 | 7 | Cameron | 14 | Spooner | 48 | |
| 10/8/2021 | 8 | Spooner | 42 | Chetek-Weyerhaeuser | 0 | |
| 10/15/2021 | 9 | Bloomer | 14 | Spooner | 43 | |