| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Pecatonica/Argyle (NC) | 6 | Waterloo | 22 | |
| 8/27/2021 | 2 | Waterloo | 40 | Westfield (NC) | 0 | |
| 9/3/2021 | 3 | Markesan | 22 | Waterloo | 12 | |
| 9/10/2021 | 4 | Waterloo | 33 | Cambridge | 14 | |
| 9/17/2021 | 5 | Marshall | 15 | Waterloo | 14 | |
| 9/24/2021 | 6 | Waterloo | 61 | Palmyra-Eagle | 0 | |
| 10/1/2021 | 7 | *Waterloo | 48 | Milwaukee Academy of Science (NC) | 12 | |
| 10/1/2021 | 7 | Waterloo | 1 | Dodgeland | 0 | |
| 10/8/2021 | 8 | Clinton | 18 | Waterloo | 33 | |
| 10/15/2021 | 9 | Pardeeville | 29 | Waterloo | 44 | |