| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Gale-Ettrick-Trempealeau (NC) | 0 | West Salem | 48 | |
| 9/3/2021 | 3 | West Salem | 10 | La Crosse Central | 0 | |
| 9/10/2021 | 4 | La Crosse Logan | 7 | West Salem | 21 | |
| 9/17/2021 | 5 | Sparta | 7 | West Salem | 33 | |
| 9/24/2021 | 6 | West Salem | 33 | Onalaska | 28 | |
| 10/1/2021 | 7 | River Falls | 41 | West Salem | 7 | |
| 10/8/2021 | 8 | West Salem | 53 | Tomah | 6 | |
| 10/15/2021 | 9 | Holmen | 21 | West Salem | 28 | |