| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Wisconsin Lutheran | 27 | New Berlin Eisenhower (NC) | 21 | |
| 8/27/2021 | 2 | Waukesha North (NC) | 21 | Wisconsin Lutheran | 30 | |
| 9/3/2021 | 3 | *Wisconsin Lutheran | 34 | *Racine Lutheran (NC) | 41 | |
| 9/3/2021 | 3 | Wisconsin Lutheran | 1 | Shorewood/Messmer | 0 | |
| 9/10/2021 | 4 | Grafton | 49 | Wisconsin Lutheran | 7 | |
| 9/17/2021 | 5 | Greendale | 28 | Wisconsin Lutheran | 20 | |
| 9/24/2021 | 6 | Wisconsin Lutheran | 44 | South Milwaukee | 7 | |
| 10/1/2021 | 7 | Greenfield | 14 | Wisconsin Lutheran | 49 | |
| 10/8/2021 | 8 | Wisconsin Lutheran | 56 | Cudahy | 8 | |
| 10/14/2021 | 9 | Whitnall | 42 | Wisconsin Lutheran | 35 | |