| Date | Week | Home | Score | Away | Score | |
| 8/19/2021 | 1 | Lourdes Academy (NC) | 52 | North Fond du Lac | 18 | |
| 8/27/2021 | 2 | New Holstein (NC) | 48 | North Fond du Lac | 6 | |
| 9/3/2021 | 3 | Winnebago Lutheran Academy | 40 | North Fond du Lac | 0 | |
| 9/10/2021 | 4 | North Fond du Lac | 0 | Mayville | 66 | |
| 9/17/2021 | 5 | Lomira | 55 | North Fond du Lac | 18 | |
| 9/24/2021 | 6 | North Fond du Lac | 0 | St. Mary's Springs | 76 | |
| 10/1/2021 | 7 | North Fond du Lac | 6 | Laconia | 62 | |
| 10/8/2021 | 8 | North Fond du Lac | 12 | Campbellsport | 72 | |
| 10/15/2021 | 9 | Omro | 63 | North Fond du Lac | 6 | |