| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Milwaukee Bradley Tech/Milw Arts | 1 | Milwaukee Washington/Fuller Collegiate | 0 | |
| 9/2/2021 | 3 | Milwaukee Riverside/Golda Meir | 1 | Milwaukee Washington/Fuller Collegiate | 0 | |
| 9/17/2021 | 5 | Milwaukee King | 1 | Milwaukee Washington/Fuller Collegiate | 0 | |
| 9/17/2021 | 5 | *Milwaukee Washington/Fuller Collegiate | 6 | Milwaukee Vincent/Destiny (NC) | 20 | |
| 9/23/2021 | 6 | Milwaukee Washington/Fuller Collegiate | 12 | *Milwaukee Madison (NC) | 6 | |
| 10/1/2021 | 7 | *Milwaukee Pulaski/Carmen South/Carmen SE (NC) | 50 | Milwaukee Washington/Fuller Collegiate | 16 | |