| Week | Date | Home | Score | Away | Score | |
| 6 | 9/23/2021 | Carmen Schools | | Milwaukee Vincent/Destiny | | |
| 6 | 9/23/2021 | Milwaukee Vincent/Destiny | | Milwaukee Pulaski/Carmen South/Carmen SE | | |
| 6 | 9/23/2021 | Milwaukee Washington/Fuller Collegiate | | Milwaukee Madison | | |
| 6 | 9/23/2021 | Assumption | | Pittsville | | |
| 6 | 9/23/2021 | Brookfield Academy | | Dominican | | |
| 6 | 9/24/2021 | Milwaukee North | | Milwaukee Hamilton/Audubon Tech | | |
| 6 | 9/24/2021 | Menominee Indian | | Tomahawk | | |
| 6 | 9/24/2021 | Marathon | | Kingdom Prep Lutheran | | |
| 6 | 9/24/2021 | Oshkosh West | | Kimberly | | |
| 6 | 9/24/2021 | La Crosse Central | | Tomah | | |
| 6 | 9/24/2021 | Milwaukee Bradley Tech/Milw Arts | | Milwaukee Bay View/Milw Lifelong Learning | | |
| 6 | 9/24/2021 | Milwaukee Riverside/Golda Meir | | Milwaukee King | | |
| 6 | 9/24/2021 | Milwaukee Washington/Fuller Collegiate | | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | | |
| 6 | 9/24/2021 | Altoona | | Gale-Ettrick-Trempealeau | | |
| 6 | 9/24/2021 | Amherst | | TBA | | |
| 6 | 9/24/2021 | Appleton East | | Appleton North | | |
| 6 | 9/24/2021 | Aquinas | | Arcadia | | |
| 6 | 9/24/2021 | Ashland | | Merrill | | |
| 6 | 9/24/2021 | Auburndale | | Abbotsford | | |
| 6 | 9/24/2021 | Augusta | | Pepin/Alma | | |
| 6 | 9/24/2021 | Badger | | Burlington | | |
| 6 | 9/24/2021 | Beloit Memorial | | Madison East | | |
| 6 | 9/24/2021 | Berlin | | Kewaskum | | |
| 6 | 9/24/2021 | Black River Falls | | Westby | | |
| 6 | 9/24/2021 | Blair-Taylor | | Whitehall | | |
| 6 | 9/24/2021 | Bloomer | | Saint Croix Falls | | |
| 6 | 9/24/2021 | Brookfield Central | | Marquette University | | |
| 6 | 9/24/2021 | Cambridge | | Pardeeville | | |
| 6 | 9/24/2021 | Campbellsport | | Winnebago Lutheran Academy | | |
| 6 | 9/24/2021 | Catholic Central | | St Joseph Catholic Academy | | |
| 6 | 9/24/2021 | Catholic Memorial | | Wauwatosa West | | |
| 6 | 9/24/2021 | Cedar Grove-Belgium | | Ozaukee | | |
| 6 | 9/24/2021 | Cedarburg | | Slinger | | |
| 6 | 9/24/2021 | Chilton | | Roncalli | | |
| 6 | 9/24/2021 | Cochrane-Fountain City | | Melrose-Mindoro | | |
| 6 | 9/24/2021 | Colfax | | Spring Valley | | |
| 6 | 9/24/2021 | Columbus | | Watertown Luther Prep | | |
| 6 | 9/24/2021 | Crandon | | Niagara/Goodman/Pembine | | |
| 6 | 9/24/2021 | Crivitz | | Northland Pines | | |
| 6 | 9/24/2021 | Cuba City | | River Ridge | | |
| 6 | 9/24/2021 | Cudahy | | Greendale | | |
| 6 | 9/24/2021 | Cumberland | | Cameron | | |
| 6 | 9/24/2021 | Darlington | | Fennimore | | |
| 6 | 9/24/2021 | De Pere | | West De Pere | | |
| 6 | 9/24/2021 | De Soto | | Wauzeka-Steuben/Seneca | | |
| 6 | 9/24/2021 | Deerfield | | Cambria-Friesland | | |
| 6 | 9/24/2021 | DeForest | | Waunakee | | |
| 6 | 9/24/2021 | Dodgeland | | Marshall | | |
| 6 | 9/24/2021 | Durand | | Elk Mound | | |
| 6 | 9/24/2021 | East Troy | | Monroe | | |
| 6 | 9/24/2021 | Eau Claire Memorial | | Superior | | |
| 6 | 9/24/2021 | Edgerton | | Edgewood | | |
| 6 | 9/24/2021 | Elmwood/Plum City | | Cadott | | |
| 6 | 9/24/2021 | Fall Creek | | Regis | | |
| 6 | 9/24/2021 | Fall River/Rio | | St. John's Northwestern | | |
| 6 | 9/24/2021 | Fond du Lac | | Kaukauna | | |
| 6 | 9/24/2021 | Fort Atkinson | | Baraboo | | |
| 6 | 9/24/2021 | Fox Valley Lutheran | | Seymour | | |
| 6 | 9/24/2021 | Germantown | | Brookfield East | | |
| 6 | 9/24/2021 | Glenwood City | | Clear Lake | | |
| 6 | 9/24/2021 | Grantsburg | | Webster | | |
| 6 | 9/24/2021 | Green Bay Preble | | Ashwaubenon | | |
| 6 | 9/24/2021 | Green Bay Southwest | | Green Bay East | | |
| 6 | 9/24/2021 | Hayward/Lac Courte Oreilles | | Medford | | |
| 6 | 9/24/2021 | Hillsboro | | Boscobel | | |
| 6 | 9/24/2021 | Holmen | | Sparta | | |
| 6 | 9/24/2021 | Homestead | | West Bend West | | |
| 6 | 9/24/2021 | Horicon/Hustisford | | Big Foot | | |
| 6 | 9/24/2021 | Hudson | | Eau Claire North | | |
| 6 | 9/24/2021 | Hurley | | Edgar | | |
| 6 | 9/24/2021 | Hurley | | Lake Holcombe | | |
| 6 | 9/24/2021 | Iowa-Grant | | Benton/Scales Mound IL/Shullsburg | | |
| 6 | 9/24/2021 | Janesville Parker | | Janesville Craig | | |
| 6 | 9/24/2021 | Jefferson | | Whitewater | | |
| 6 | 9/24/2021 | Johnson Creek | | Randolph | | |
| 6 | 9/24/2021 | Kenosha Bradford/Kenosha Reuther | | Franklin | | |
| 6 | 9/24/2021 | Kenosha Christian Life | | Racine Lutheran | | |
| 6 | 9/24/2021 | Kettle Moraine | | Waukesha West | | |
| 6 | 9/24/2021 | Kewaunee | | Bonduel | | |
| 6 | 9/24/2021 | Kohler/Sheboygan Christian/Sheboygan Lutheran | | Kiel | | |
| 6 | 9/24/2021 | Laconia | | Mayville | | |
| 6 | 9/24/2021 | Ladysmith | | Flambeau | | |
| 6 | 9/24/2021 | Lake Mills | | Turner | | |
| 6 | 9/24/2021 | Lakeland | | Mosinee | | |
| 6 | 9/24/2021 | Lakeside Lutheran | | Lodi | | |
| 6 | 9/24/2021 | Lancaster | | Mineral Point | | |
| 6 | 9/24/2021 | Little Chute | | Wrightstown | | |
| 6 | 9/24/2021 | Loyal | | Ladysmith | | |
| 6 | 9/24/2021 | Luxemburg-Casco | | Marinette | | |
| 6 | 9/24/2021 | Madison La Follette | | Verona | | |
| 6 | 9/24/2021 | Madison Memorial | | Middleton | | |
| 6 | 9/24/2021 | Manitowoc Lincoln | | Sheboygan North | | |
| 6 | 9/24/2021 | Manitowoc Lutheran | | Hilbert | | |
| 6 | 9/24/2021 | Marathon | | Colby | | |
| 6 | 9/24/2021 | Marathon | | Owen-Withee | | |
| 6 | 9/24/2021 | Markesan | | Clinton | | |
| 6 | 9/24/2021 | Marshfield | | Wausau West | | |
| 6 | 9/24/2021 | Martin Luther | | Shoreland Lutheran | | |
| 6 | 9/24/2021 | Mauston | | Dodgeville | | |
| 6 | 9/24/2021 | McFarland | | Evansville | | |
| 6 | 9/24/2021 | Menominee (MI) | | Denmark | | |
| 6 | 9/24/2021 | Menomonee Falls | | Appleton West | | |
| 6 | 9/24/2021 | Milwaukee Lutheran | | New Berlin West | | |
| 6 | 9/24/2021 | Mondovi | | Neillsville/Granton | | |
| 6 | 9/24/2021 | Monona Grove | | Sauk Prairie | | |
| 6 | 9/24/2021 | Mount Horeb/Barneveld | | Stoughton | | |
| 6 | 9/24/2021 | Mukwonago | | Waukesha North | | |
| 6 | 9/24/2021 | Muskego | | Arrowhead | | |
| 6 | 9/24/2021 | Necedah | | Cashton | | |
| 6 | 9/24/2021 | Neenah | | Oshkosh North | | |
| 6 | 9/24/2021 | New Berlin Eisenhower | | Pius XI Catholic | | |
| 6 | 9/24/2021 | New Holstein | | Brillion | | |
| 6 | 9/24/2021 | New Lisbon | | Brookwood | | |
| 6 | 9/24/2021 | New London | | Winneconne | | |
| 6 | 9/24/2021 | New Richmond | | Menomonie | | |
| 6 | 9/24/2021 | Nicolet | | Hartford Union | | |
| 6 | 9/24/2021 | North Fond du Lac | | Saint Mary's Springs | | |
| 6 | 9/24/2021 | Northwestern | | Chetek-Weyerhaeuser | | |
| 6 | 9/24/2021 | Notre Dame | | Menasha | | |
| 6 | 9/24/2021 | Notre Dame | | Menasha | | |
| 6 | 9/24/2021 | Oak Creek | | Kenosha Indian Trail | | |
| 6 | 9/24/2021 | Oconto | | Mishicot | | |
| 6 | 9/24/2021 | Oconto Falls | | Coleman | | |
| 6 | 9/24/2021 | Omro | | Lomira | | |
| 6 | 9/24/2021 | Oregon | | Beaver Dam | | |
| 6 | 9/24/2021 | Osceola | | Ellsworth | | |
| 6 | 9/24/2021 | Osseo-Fairchild | | Stanley-Boyd | | |
| 6 | 9/24/2021 | Parkview/Albany | | Belleville | | |
| 6 | 9/24/2021 | Platteville | | Prairie du Chien | | |
| 6 | 9/24/2021 | Plymouth | | Port Washington | | |
| 6 | 9/24/2021 | Potosi/Cassville | | Pecatonica/Argyle | | |
| 6 | 9/24/2021 | Poynette | | Adams-Friendship | | |
| 6 | 9/24/2021 | Prescott | | Baldwin-Woodville | | |
| 6 | 9/24/2021 | Pulaski | | Bay Port | | |
| 6 | 9/24/2021 | Racine Case | | Kenosha Tremper | | |
| 6 | 9/24/2021 | Racine Park | | Racine Horlick | | |
| 6 | 9/24/2021 | Racine Saint Catherine’s | | Brown Deer | | |
| 6 | 9/24/2021 | Random Lake | | Howards Grove | | |
| 6 | 9/24/2021 | Reedsburg | | Portage | | |
| 6 | 9/24/2021 | Reedsville | | Oostburg | | |
| 6 | 9/24/2021 | Rhinelander | | Antigo | | |
| 6 | 9/24/2021 | Rice Lake | | Chippewa Falls | | |
| 6 | 9/24/2021 | Richland Center | | New Glarus/Monticello | | |
| 6 | 9/24/2021 | Ripon | | Waupun | | |
| 6 | 9/24/2021 | River Valley | | Brodhead/Juda | | |
| 6 | 9/24/2021 | Riverdale | | Highland | | |
| 6 | 9/24/2021 | Royall | | Bangor | | |
| 6 | 9/24/2021 | Saint Croix Central | | Amery | | |
| 6 | 9/24/2021 | Saint Francis | | Lake Country Lutheran | | |
| 6 | 9/24/2021 | Sheboygan Falls | | Kettle Moraine Lutheran | | |
| 6 | 9/24/2021 | Sheboygan South | | Green Bay West | | |
| 6 | 9/24/2021 | Shiocton | | Manawa | | |
| 6 | 9/24/2021 | Shorewood/Messmer | | Greenfield | | |
| 6 | 9/24/2021 | Southern Door | | Clintonville | | |
| 6 | 9/24/2021 | Southwestern | | Black Hawk/Warren IL | | |
| 6 | 9/24/2021 | Spencer/Columbus Catholic | | Nekoosa | | |
| 6 | 9/24/2021 | Spooner | | Barron | | |
| 6 | 9/24/2021 | Stevens Point | | D.C. Everest | | |
| 6 | 9/24/2021 | Stratford | | Wittenberg-Birnamwood | | |
| 6 | 9/24/2021 | Thorp | | Colby | | |
| 6 | 9/24/2021 | Turtle Lake | | Boyceville | | |
| 6 | 9/24/2021 | Two Rivers | | Valders | | |
| 6 | 9/24/2021 | Union Grove | | Delavan-Darien | | |
| 6 | 9/24/2021 | Unity | | Rib Lake/Prentice | | |
| 6 | 9/24/2021 | University School of Milwaukee | | Saint Thomas More | | |
| 6 | 9/24/2021 | Viroqua | | Somerset | | |
| 6 | 9/24/2021 | Waterford | | Westosha Central | | |
| 6 | 9/24/2021 | Waterloo | | Palmyra-Eagle | | |
| 6 | 9/24/2021 | Watertown | | Milton | | |
| 6 | 9/24/2021 | Waukesha South | | Oconomowoc | | |
| 6 | 9/24/2021 | Waupaca | | Freedom | | |
| 6 | 9/24/2021 | Wausau East | | Appleton West | | |
| 6 | 9/24/2021 | Wautoma | | Montello/Green Lake/Princeton | | |
| 6 | 9/24/2021 | Wauwatosa East | | Pewaukee | | |
| 6 | 9/24/2021 | West Allis Hale | | Hamilton | | |
| 6 | 9/24/2021 | West Bend East | | Whitefish Bay | | |
| 6 | 9/24/2021 | West Salem | | Onalaska | | |
| 6 | 9/24/2021 | Whitnall | | Grafton | | |
| 6 | 9/24/2021 | Wild Rose | | Iola-Scandinavia | | |
| 6 | 9/24/2021 | Wilmot Union | | Elkhorn Area | | |
| 6 | 9/24/2021 | Wisconsin Dells | | Westfield | | |
| 6 | 9/24/2021 | Wisconsin Lutheran | | South Milwaukee | | |
| 6 | 9/24/2021 | Wisconsin Rapids Lincoln | | Hortonville | | |
| 6 | 9/24/2021 | Catholic Memorial | | Wauwatosa West | | |
| 6 | 9/24/2021 | Lourdes Academy | | Peshtigo | | |
| 6 | 9/25/2021 | Living Word Lutheran | | Kingdom Prep Lutheran | | |
| 6 | 9/25/2021 | Pacelli | | Rosholt | | |
| 6 | 9/25/2021 | Shawano Community | | Xavier | | |
| 6 | 9/25/2021 | Ithaca | | Luther | | |
| 6 | 9/25/2021 | Ithaca High School | | Luther | | |