| Week | Date | Home | Score | Away | Score | |
| 9 | 10/13/2022 | Milwaukee Bay View/Milw Lifelong Learning | 56 | Milwaukee North | 6 | |
| 9 | 10/13/2022 | Milwaukee Reagan | 34 | Milwaukee South | 8 | |
| 9 | 10/13/2022 | Milwaukee Vincent/Destiny | 6 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 40 | |
| 9 | 10/13/2022 | Obama SCTE | 8 | Milwaukee Bradley Tech/Milw Arts | 12 | |
| 9 | 10/13/2022 | Assumption | 76 | Rosholt | 0 | |
| 9 | 10/13/2022 | Ithaca | 54 | Hillsboro | 16 | |
| 9 | 10/13/2022 | Regis | 56 | Neillsville/Granton | 13 | |
| 9 | 10/13/2022 | Shawano | 48 | Seymour | 12 | |
| 9 | 10/13/2022 | St. Mary's Springs | 17 | Mayville | 27 | |
| 9 | 10/13/2022 | Turner | 41 | Big Foot | 0 | |
| 9 | 10/13/2022 | Lourdes Academy | 26 | Randolph | 44 | |
| 9 | 10/14/2022 | St. John's NW Academies | 0 | Cambria-Friesland | 1 | Forfeit |
| 9 | 10/14/2022 | Menominee Indian | 0 | Northland Pines | 34 | |
| 9 | 10/14/2022 | Milwaukee Hamilton/Audubon Tech | 47 | Milwaukee Washington/Fuller Collegiate | 8 | |
| 9 | 10/14/2022 | Iola-Scandinavia | 24 | Kingdom Prep Lutheran | 30 | |
| 9 | 10/14/2022 | Kenosha Bradford/Kenosha Reuther | 7 | Franklin | 35 | |
| 9 | 10/14/2022 | Milwaukee Riverside/Golda Meir | 43 | Milwaukee Madison | 0 | |
| 9 | 10/14/2022 | Adams-Friendship | 48 | Mauston | 8 | |
| 9 | 10/14/2022 | Appleton East | 7 | Neenah | 35 | |
| 9 | 10/14/2022 | Appleton West | 14 | Stevens Point | 7 | |
| 9 | 10/14/2022 | Aquinas | 14 | West Salem | 28 | |
| 9 | 10/14/2022 | Arcadia | 14 | Gale-Ettrick-Trempealeau | 50 | |
| 9 | 10/14/2022 | Arrowhead | 42 | Oconomowoc | 7 | |
| 9 | 10/14/2022 | Ashland | 26 | Hayward/Lac Courte Oreilles | 20 | |
| 9 | 10/14/2022 | Ashwaubenon | 28 | De Pere | 35 | |
| 9 | 10/14/2022 | Augusta | 54 | Independence/Gilmanton | 13 | |
| 9 | 10/14/2022 | Baldwin-Woodville | 38 | Amery | 7 | |
| 9 | 10/14/2022 | Bangor | 41 | New Lisbon | 6 | |
| 9 | 10/14/2022 | Baraboo | 35 | Sparta | 7 | |
| 9 | 10/14/2022 | Barron | 0 | St. Croix Falls | 1 | Forfeit |
| 9 | 10/14/2022 | Bay Port | 34 | West De Pere | 27 | |
| 9 | 10/14/2022 | Beaver Dam | 0 | Waunakee | 42 | |
| 9 | 10/14/2022 | Belleville | 58 | Parkview/Albany | 6 | |
| 9 | 10/14/2022 | Beloit Memorial | 7 | Badger | 35 | |
| 9 | 10/14/2022 | Berlin | 12 | Port Washington | 29 | |
| 9 | 10/14/2022 | Black Hawk/Warren, IL | 48 | Pecatonica/Argyle | 0 | |
| 9 | 10/14/2022 | Black River Falls | 24 | Viroqua | 22 | |
| 9 | 10/14/2022 | Blair-Taylor | 49 | Eleva-Strum | 8 | |
| 9 | 10/14/2022 | Bloomer | 6 | Northwestern | 22 | |
| 9 | 10/14/2022 | Bonduel | 28 | Oconto | 6 | |
| 9 | 10/14/2022 | Boscobel | 0 | Wauzeka-Steuben/Seneca | 33 | |
| 9 | 10/14/2022 | Brodhead/Juda | 39 | Lancaster | 16 | |
| 9 | 10/14/2022 | Brookwood | 0 | Iowa-Grant | 28 | |
| 9 | 10/14/2022 | Brown Deer | 0 | Saint Thomas More | 20 | |
| 9 | 10/14/2022 | Cadott | 14 | Boyceville | 45 | |
| 9 | 10/14/2022 | Cambria-Friesland | 32 | Kenosha Christian Life | 26 | |
| 9 | 10/14/2022 | Campbellsport | 48 | Lomira | 27 | |
| 9 | 10/14/2022 | Cashton | 34 | Luther | 0 | |
| 9 | 10/14/2022 | Cedarburg | 21 | Whitefish Bay | 28 | |
| 9 | 10/14/2022 | Chetek-Weyerhaeuser | 0 | Spooner | 35 | |
| 9 | 10/14/2022 | Chilton | 21 | Two Rivers | 29 | |
| 9 | 10/14/2022 | Chippewa Falls | 42 | Superior | 7 | |
| 9 | 10/14/2022 | Clear Lake | 34 | Colfax | 14 | |
| 9 | 10/14/2022 | Clinton | 48 | Cambridge | 0 | |
| 9 | 10/14/2022 | Clintonville | 46 | Tomahawk | 0 | |
| 9 | 10/14/2022 | Cochrane-Fountain City | 14 | Pepin/Alma | 46 | |
| 9 | 10/14/2022 | Colby | 14 | Auburndale | 20 | |
| 9 | 10/14/2022 | Columbus | 56 | New Glarus/Monticello | 14 | |
| 9 | 10/14/2022 | Crandon | 12 | Coleman | 36 | |
| 9 | 10/14/2022 | Crivitz | 35 | Oconto Falls | 6 | |
| 9 | 10/14/2022 | Cudahy | 0 | Greenfield | 1 | Forfeit |
| 9 | 10/14/2022 | Cumberland | 34 | Cameron | 15 | |
| 9 | 10/14/2022 | DeForest | 36 | Sauk Prairie | 18 | |
| 9 | 10/14/2022 | Delavan-Darien | 7 | Edgerton | 14 | |
| 9 | 10/14/2022 | Denmark | 7 | Little Chute | 13 | |
| 9 | 10/14/2022 | Dodgeland | 8 | Palmyra-Eagle | 43 | |
| 9 | 10/14/2022 | Dodgeville | 53 | Richland Center | 20 | |
| 9 | 10/14/2022 | Dominican | 0 | Kenosha Christian Life | 1 | Forfeit |
| 9 | 10/14/2022 | Eau Claire North | 19 | River Falls | 31 | |
| 9 | 10/14/2022 | Edgar | 35 | Marathon | 0 | |
| 9 | 10/14/2022 | Edgewood | 10 | Lakeside Lutheran | 13 | |
| 9 | 10/14/2022 | Ellsworth | 32 | St. Croix Central | 14 | |
| 9 | 10/14/2022 | Fall Creek | 38 | Osseo-Fairchild | 0 | |
| 9 | 10/14/2022 | Fall River/Rio | 14 | Deerfield | 19 | |
| 9 | 10/14/2022 | Fennimore | 13 | Darlington | 66 | |
| 9 | 10/14/2022 | Flambeau | 0 | Ladysmith | 1 | Forfeit |
| 9 | 10/14/2022 | Fond du Lac | 35 | Oshkosh West | 10 | |
| 9 | 10/14/2022 | Fort Atkinson | 14 | Monona Grove | 48 | |
| 9 | 10/14/2022 | Freedom | 37 | Fox Valley Lutheran | 0 | |
| 9 | 10/14/2022 | Germantown | 14 | Brookfield Central | 0 | |
| 9 | 10/14/2022 | Glenwood City | 14 | Turtle Lake | 18 | |
| 9 | 10/14/2022 | Grafton | 45 | Greendale | 21 | |
| 9 | 10/14/2022 | Grantsburg | 37 | Ladysmith | 14 | |
| 9 | 10/14/2022 | Green Bay West | 6 | Sheboygan North | 59 | |
| 9 | 10/14/2022 | Hamilton | 36 | Brookfield East | 6 | |
| 9 | 10/14/2022 | Highland | 42 | Riverdale | 12 | |
| 9 | 10/14/2022 | Hilbert | 62 | Manitowoc Lutheran | 20 | |
| 9 | 10/14/2022 | Hortonville | 22 | Marshfield | 35 | |
| 9 | 10/14/2022 | Howards Grove | 35 | Random Lake | 0 | |
| 9 | 10/14/2022 | Hudson | 30 | New Richmond | 20 | |
| 9 | 10/14/2022 | Hurley | 48 | Webster | 13 | |
| 9 | 10/14/2022 | Iola-Scandinavia | 1 | Wild Rose | 0 | Forfeit |
| 9 | 10/14/2022 | Janesville Craig | 12 | Madison Memorial | 16 | |
| 9 | 10/14/2022 | Jefferson | 6 | East Troy | 20 | |
| 9 | 10/14/2022 | Johnson Creek | 48 | Pardeeville | 27 | |
| 9 | 10/14/2022 | Kenosha Indian Trail | 21 | Racine Case | 0 | |
| 9 | 10/14/2022 | Kenosha St. Joseph Catholic | 28 | Racine Lutheran | 7 | |
| 9 | 10/14/2022 | Kewaunee | 53 | Peshtigo | 0 | |
| 9 | 10/14/2022 | Kimberly | 42 | Kaukauna | 28 | |
| 9 | 10/14/2022 | La Crosse Logan | 26 | La Crosse Central | 34 | |
| 9 | 10/14/2022 | Lake Mills | 28 | Lodi | 10 | |
| 9 | 10/14/2022 | Lakeland | 49 | Rhinelander | 0 | |
| 9 | 10/14/2022 | Living Word Lutheran | 27 | Brookfield Academy | 28 | |
| 9 | 10/14/2022 | Loyal | 14 | Pacelli | 26 | |
| 9 | 10/14/2022 | Luxemburg-Casco | 15 | Wrightstown | 27 | |
| 9 | 10/14/2022 | Madison La Follette | 6 | Janesville Parker | 54 | |
| 9 | 10/14/2022 | Madison West | 0 | Verona | 44 | |
| 9 | 10/14/2022 | Marquette | 42 | West Allis Hale | 10 | |
| 9 | 10/14/2022 | Marshall | 27 | Markesan | 6 | |
| 9 | 10/14/2022 | McFarland | 35 | Evansville | 0 | |
| 9 | 10/14/2022 | Medford | 53 | Antigo | 21 | |
| 9 | 10/14/2022 | Menasha | 48 | Green Bay Southwest | 23 | |
| 9 | 10/14/2022 | Menomonie | 10 | Eau Claire Memorial | 7 | |
| 9 | 10/14/2022 | Merrill | 12 | Mosinee | 40 | |
| 9 | 10/14/2022 | Middleton | 52 | Madison East | 20 | |
| 9 | 10/14/2022 | Milton | 34 | Watertown | 0 | |
| 9 | 10/14/2022 | Milwaukee Academy of Science | 36 | Milwaukee Excellence Charter School | 0 | |
| 9 | 10/14/2022 | Milwaukee Lutheran | 8 | New Berlin West | 48 | |
| 9 | 10/14/2022 | Milwaukee Pulaski/Carmen South/Carmen SE | 0 | Milwaukee King | 34 | |
| 9 | 10/14/2022 | Mineral Point | 39 | Cuba City | 13 | |
| 9 | 10/14/2022 | Mishicot | 0 | Marinette | 30 | |
| 9 | 10/14/2022 | Mondovi | 41 | Durand-Arkansaw | 8 | |
| 9 | 10/14/2022 | Monroe | 47 | Whitewater | 0 | |
| 9 | 10/14/2022 | Montello/Green Lake/Princeton | 0 | Prairie du Chien | 1 | Forfeit |
| 9 | 10/14/2022 | Mukwonago | 45 | Waukesha West | 13 | |
| 9 | 10/14/2022 | Muskego | 17 | Kettle Moraine | 13 | |
| 9 | 10/14/2022 | Necedah | 8 | Royall | 59 | |
| 9 | 10/14/2022 | Nekoosa | 6 | Wittenberg-Birnamwood | 46 | |
| 9 | 10/14/2022 | New Berlin Eisenhower | 6 | Pewaukee | 13 | |
| 9 | 10/14/2022 | New Holstein | 0 | Kiel | 34 | |
| 9 | 10/14/2022 | Nicolet | 17 | Hartford Union | 14 | |
| 9 | 10/14/2022 | North Fond du Lac | 0 | Winnebago Lutheran | 53 | |
| 9 | 10/14/2022 | Notre Dame | 35 | Manitowoc Lincoln | 14 | |
| 9 | 10/14/2022 | Oak Creek | 49 | Kenosha Tremper | 20 | |
| 9 | 10/14/2022 | Omro | 7 | Laconia | 28 | |
| 9 | 10/14/2022 | Onalaska | 49 | Tomah | 20 | |
| 9 | 10/14/2022 | Oostburg | 21 | Reedsville | 14 | |
| 9 | 10/14/2022 | Osceola | 15 | Somerset | 14 | |
| 9 | 10/14/2022 | Oshkosh North | 6 | Appleton North | 16 | |
| 9 | 10/14/2022 | Ozaukee | 7 | Cedar Grove-Belgium | 28 | |
| 9 | 10/14/2022 | Pittsville | 41 | Abbotsford | 6 | |
| 9 | 10/14/2022 | Pius XI Catholic | 6 | Wauwatosa East | 26 | |
| 9 | 10/14/2022 | Plymouth | 52 | Kettle Moraine Lutheran | 14 | |
| 9 | 10/14/2022 | Portage | 21 | Mount Horeb/Barneveld | 39 | |
| 9 | 10/14/2022 | Potosi/Cassville | 44 | Southwestern/East Dubuque, IL | 20 | |
| 9 | 10/14/2022 | Poynette | 17 | Wisconsin Dells | 43 | |
| 9 | 10/14/2022 | Pulaski | 62 | Green Bay Preble | 14 | |
| 9 | 10/14/2022 | Racine Horlick | 36 | Racine Park | 0 | |
| 9 | 10/14/2022 | Racine St. Catherine’s | 40 | University School of Milwaukee | 13 | |
| 9 | 10/14/2022 | Reedsburg | 6 | Holmen | 24 | |
| 9 | 10/14/2022 | Rice Lake | 44 | Prescott | 14 | |
| 9 | 10/14/2022 | Ripon | 12 | Waupun | 6 | |
| 9 | 10/14/2022 | River Ridge | 21 | Benton/Scales Mound IL/Shullsburg | 0 | |
| 9 | 10/14/2022 | River Valley | 40 | Platteville | 7 | |
| 9 | 10/14/2022 | Roncalli | 27 | Kohler/Sheboygan Christian/Sheboygan Lutheran | 40 | |
| 9 | 10/14/2022 | Saint Francis | 7 | Catholic Central | 23 | |
| 9 | 10/14/2022 | Sheboygan Falls | 26 | Kewaskum | 42 | |
| 9 | 10/14/2022 | Sheboygan South | 56 | Green Bay East | 0 | |
| 9 | 10/14/2022 | Shiocton | 40 | Spencer/Columbus Catholic | 12 | |
| 9 | 10/14/2022 | Shoreland Lutheran | 19 | Lake Country Lutheran | 48 | |
| 9 | 10/14/2022 | Slinger | 42 | West Bend East | 13 | |
| 9 | 10/14/2022 | South Milwaukee | 27 | Wisconsin Lutheran | 66 | |
| 9 | 10/14/2022 | Spring Valley | 14 | Elmwood/Plum City | 12 | |
| 9 | 10/14/2022 | Stanley-Boyd | 24 | Elk Mound | 21 | |
| 9 | 10/14/2022 | Stoughton | 7 | Sun Prairie East | 76 | |
| 9 | 10/14/2022 | Stratford | 21 | Amherst | 28 | |
| 9 | 10/14/2022 | Sturgeon Bay | 0 | Southern Door | 41 | |
| 9 | 10/14/2022 | Sun Prairie West | 21 | Oregon | 0 | |
| 9 | 10/14/2022 | Union Grove | 27 | Elkhorn Area | 14 | |
| 9 | 10/14/2022 | Unity | 57 | Rib Lake/Prentice | 12 | |
| 9 | 10/14/2022 | Valders | 40 | Brillion | 14 | |
| 9 | 10/14/2022 | Waterford | 28 | Burlington | 17 | |
| 9 | 10/14/2022 | Waterloo | 31 | Horicon/Hustisford | 7 | |
| 9 | 10/14/2022 | Watertown Luther Prep | 7 | Martin Luther | 35 | |
| 9 | 10/14/2022 | Waukesha North | 1 | Waukesha South | 0 | Forfeit |
| 9 | 10/14/2022 | Waupaca | 17 | Winneconne | 35 | |
| 9 | 10/14/2022 | Wausau West | 40 | D.C. Everest | 14 | |
| 9 | 10/14/2022 | Wautoma | 42 | Westfield | 26 | |
| 9 | 10/14/2022 | West Allis Central | 0 | Menomonee Falls | 41 | |
| 9 | 10/14/2022 | West Bend West | 0 | Homestead | 35 | |
| 9 | 10/14/2022 | Westby | 27 | Altoona | 12 | |
| 9 | 10/14/2022 | Westosha Central | 42 | Wilmot Union | 7 | |
| 9 | 10/14/2022 | Weyauwega-Fremont | 27 | Manawa | 24 | |
| 9 | 10/14/2022 | Whitehall | 7 | Melrose-Mindoro | 27 | |
| 9 | 10/14/2022 | Whitnall | 50 | Shorewood/Messmer | 12 | |
| 9 | 10/14/2022 | Wisconsin Rapids Lincoln | 51 | Menominee (MI) | 44 | |
| 9 | 10/14/2022 | Wisconsin Rapids Lincoln | 1 | Wausau East | 0 | Forfeit |
| 9 | 10/14/2022 | Xavier | 45 | New London | 0 | |
| 9 | 10/14/2022 | Catholic Memorial | 42 | Wauwatosa West | 0 | |