| Week | Date | Home | Score | Away | Score | |
| 5 | 9/17/2026 | Milwaukee School of Languages | 28 | Milwaukee Hamilton/Audubon Technology | 30 | |
| 5 | 9/17/2026 | Milwaukee Pulaski/Carmen Southgate | 12 | Milwaukee Bay View | 20 | |
| 5 | 9/17/2026 | Milwaukee South | 0 | Dr. Howard Fuller Collegiate Academy | 1 | Forfeit |
| 5 | 9/17/2026 | Milwaukee Washington | | Milwaukee North/Milwaukee WI Conservatory of Lifelong Learning | | |
| 5 | 9/17/2026 | Abbotsford | 20 | Pacelli | 19 | |
| 5 | 9/17/2026 | Appleton West | 0 | West De Pere | 42 | |
| 5 | 9/17/2026 | Arcadia | 22 | Luther | 6 | |
| 5 | 9/17/2026 | Ashwaubenon | 0 | Pulaski | 35 | |
| 5 | 9/17/2026 | Bangor | 43 | Necedah | 0 | |
| 5 | 9/17/2026 | Bay Port | 44 | De Pere | 7 | |
| 5 | 9/17/2026 | Blair-Taylor | 32 | Eleva-Strum | 34 | |
| 5 | 9/17/2026 | Cadott | 26 | Boyceville | 12 | |
| 5 | 9/17/2026 | Green Bay East | 0 | Notre Dame | 70 | |
| 5 | 9/17/2026 | Green Bay Preble | 42 | Green Bay Southwest | 14 | |
| 5 | 9/17/2026 | La Crosse Central | 29 | La Crosse Logan | 37 | |
| 5 | 9/17/2026 | Madison East | 6 | Madison Memorial | 49 | |
| 5 | 9/17/2026 | Menasha | 48 | Green Bay West | 8 | |
| 5 | 9/17/2026 | Onalaska | 42 | Baraboo | 6 | |
| 5 | 9/17/2026 | Oshkosh North | 21 | Sheboygan North | 17 | |
| 5 | 9/17/2026 | Sheboygan South | 12 | Manitowoc Lincoln | 10 | |
| 5 | 9/17/2026 | Wittenberg-Birnamwood | 56 | Spencer/Columbus Catholic | 28 | |
| 5 | 9/18/2026 | Ashland | | Saint Croix Falls | | |
| 5 | 9/18/2026 | Catholic Central | 0 | Kenosha St. Joseph Catholic | 1 | Forfeit |
| 5 | 9/18/2026 | Catholic Central/Kenosha Christian Life | | Kenosha St. Joseph Catholic | | |
| 5 | 9/18/2026 | Darlington | 49 | Southwestern/East Dubuque (IL) | 7 | |
| 5 | 9/18/2026 | Fall Creek | 39 | Neillsville/Granton | 0 | |
| 5 | 9/18/2026 | Greenfield | 27 | Whitnall | 22 | |
| 5 | 9/18/2026 | Mount Horeb/Barneveld | 50 | Fort Atkinson | 6 | |
| 5 | 9/18/2026 | Pardeeville | 34 | Poynette | 0 | |
| 5 | 9/18/2026 | Parkview/Albany | 0 | Fall River/Rio | 49 | |
| 5 | 9/18/2026 | Stoughton | 7 | Beaver Dam | 40 | |
| 5 | 9/18/2026 | Turner | 41 | Clinton | 0 | |
| 5 | 9/18/2026 | Wautoma | | Nekoosa | | |
| 5 | 9/18/2026 | Milwaukee Madison | 0 | Obama SCTE | 1 | Forfeit |
| 5 | 9/18/2026 | Kenosha Bradford | 49 | Kenosha Tremper | 0 | |
| 5 | 9/18/2026 | Milwaukee Marshall/Carmen Northwest/Milwaukee Juneau | 0 | Milwaukee Riverside/Golda Meir | 1 | Forfeit |
| 5 | 9/18/2026 | Milwaukee Reagan | 16 | Milwaukee Bradley Tech/Milwaukee Arts | 26 | |
| 5 | 9/18/2026 | Racine Case | 68 | Racine Horlick | 0 | |
| 5 | 9/18/2026 | Altoona | 34 | Prescott | 12 | |
| 5 | 9/18/2026 | Amherst | 50 | Coleman | 12 | |
| 5 | 9/18/2026 | Appleton North | 14 | Kaukauna | 0 | |
| 5 | 9/18/2026 | Arrowhead | 47 | Kettle Moraine | 0 | |
| 5 | 9/18/2026 | Auburndale | 35 | Pittsville | 0 | |
| 5 | 9/18/2026 | Augusta | 12 | Independence/Gilmanton | 8 | |
| 5 | 9/18/2026 | Badger | 7 | Elkhorn Area | 14 | |
| 5 | 9/18/2026 | Baldwin-Woodville | 24 | Amery | 7 | |
| 5 | 9/18/2026 | Barron | 16 | Spooner | 8 | |
| 5 | 9/18/2026 | Berlin | 46 | Mauston | 28 | |
| 5 | 9/18/2026 | Boscobel | | River Ridge | | |
| 5 | 9/18/2026 | Brookfield Academy | 22 | Living Word Lutheran | 30 | |
| 5 | 9/18/2026 | Brookfield Central | 28 | Hamilton | 35 | |
| 5 | 9/18/2026 | Brookfield East | 14 | Germantown | 28 | |
| 5 | 9/18/2026 | Brown Deer | 12 | Dr. Howard Fuller Collegiate Academy | 0 | |
| 5 | 9/18/2026 | Brown Deer | 1 | Shorewood/Dominican/Messmer | 0 | Forfeit |
| 5 | 9/18/2026 | Burlington | | Beloit Memorial | | |
| 5 | 9/18/2026 | Campbellsport | 12 | Mayville | 10 | |
| 5 | 9/18/2026 | Catholic Memorial | | Marquette | | |
| 5 | 9/18/2026 | Cedarburg | | Homestead | | |
| 5 | 9/18/2026 | Clintonville | | Crivitz | | |
| 5 | 9/18/2026 | Cochrane-Fountain City | | Pepin/Alma | | |
| 5 | 9/18/2026 | Crandon | | Shiocton | | |
| 5 | 9/18/2026 | Cuba City | | Fennimore | | |
| 5 | 9/18/2026 | Cudahy | 0 | Racine Lutheran | 83 | |
| 5 | 9/18/2026 | Cumberland | | Northwestern | | |
| 5 | 9/18/2026 | D.C. Everest | 71 | Eau Claire North | 7 | |
| 5 | 9/18/2026 | Deerfield | 0 | Randolph/Cambria-Friesland | 51 | |
| 5 | 9/18/2026 | DeForest | | Waunakee | | |
| 5 | 9/18/2026 | Delavan-Darien | 42 | Big Foot | 0 | |
| 5 | 9/18/2026 | Dodgeville | 20 | Benton/Scales Mound (IL)/Shullsburg | 31 | |
| 5 | 9/18/2026 | Durand-Arkansaw | 20 | Regis | 15 | |
| 5 | 9/18/2026 | East Troy | 16 | Jefferson | 24 | |
| 5 | 9/18/2026 | Eau Claire Memorial | | Superior | | |
| 5 | 9/18/2026 | Edgar | 37 | Milwaukee Riverside/Golda Meir | 6 | |
| 5 | 9/18/2026 | Edgerton | 38 | Portage | 28 | |
| 5 | 9/18/2026 | Ellsworth | 0 | Saint Croix Central | 42 | |
| 5 | 9/18/2026 | Evansville | 43 | Whitewater | 0 | |
| 5 | 9/18/2026 | Fond du Lac | 36 | Appleton East | 0 | |
| 5 | 9/18/2026 | Fox Valley Lutheran | 33 | New London | 8 | |
| 5 | 9/18/2026 | Gale-Ettrick-Trempealeau | | Aquinas | | |
| 5 | 9/18/2026 | Glenwood City | 40 | McDonell Central Catholic | 0 | |
| 5 | 9/18/2026 | Grantsburg | | Chetek-Weyerhaeuser | | |
| 5 | 9/18/2026 | Greendale | 41 | West Allis Central | 6 | |
| 5 | 9/18/2026 | Hartford Union | 18 | Waukesha West | 35 | |
| 5 | 9/18/2026 | Hayward/Lac Courte Oreilles | 6 | Bloomer | 15 | |
| 5 | 9/18/2026 | Hilbert | 48 | Mishicot | 0 | |
| 5 | 9/18/2026 | Hillsboro | 7 | Cashton | 28 | |
| 5 | 9/18/2026 | Horicon/Hustisford | 8 | Belleville | 35 | |
| 5 | 9/18/2026 | Hortonville | | Kimberly | | |
| 5 | 9/18/2026 | Iowa-Grant | 34 | Potosi/Cassville | 6 | |
| 5 | 9/18/2026 | Janesville Craig | 24 | Middleton | 52 | |
| 5 | 9/18/2026 | Johnson Creek | | Dodgeland | | |
| 5 | 9/18/2026 | Kenosha Christian Life | 0 | Pius XI Catholic | 1 | Forfeit |
| 5 | 9/18/2026 | Kewaskum | 17 | Grafton | 22 | |
| 5 | 9/18/2026 | Kohler/Sheboygan Christian/Sheboygan Lutheran | | Freedom | | |
| 5 | 9/18/2026 | Laconia | 34 | North Fond du Lac | 16 | |
| 5 | 9/18/2026 | Ladysmith | 6 | Unity | 34 | |
| 5 | 9/18/2026 | Lakeland | 6 | Tomahawk | 27 | |
| 5 | 9/18/2026 | Lakeside Lutheran | 50 | Columbus | 0 | |
| 5 | 9/18/2026 | Lancaster | | Richland Center | | |
| 5 | 9/18/2026 | Little Chute | 55 | Sheboygan Falls | 0 | |
| 5 | 9/18/2026 | Lodi | 0 | Lake Mills | 42 | |
| 5 | 9/18/2026 | Lourdes Academy | 38 | Westfield | 8 | |
| 5 | 9/18/2026 | Loyal/Greenwood | | Elk Mound | | |
| 5 | 9/18/2026 | Madison West | 20 | Madison La Follette | 59 | |
| 5 | 9/18/2026 | Marathon | 34 | Colby | 0 | |
| 5 | 9/18/2026 | Marshall | | Waterloo | | |
| 5 | 9/18/2026 | Marshfield | 39 | Wisconsin Rapids Lincoln | 0 | |
| 5 | 9/18/2026 | Martin Luther | 27 | Shoreland Lutheran | 34 | |
| 5 | 9/18/2026 | McFarland | 21 | Monroe | 14 | |
| 5 | 9/18/2026 | Merrill | 13 | Mosinee | 0 | |
| 5 | 9/18/2026 | Milton | 27 | Oregon | 21 | |
| 5 | 9/18/2026 | Mineral Point | 21 | New Glarus | 28 | |
| 5 | 9/18/2026 | Mondovi | 48 | Stanley-Boyd | 20 | |
| 5 | 9/18/2026 | Mukwonago | 3 | Franklin | 31 | |
| 5 | 9/18/2026 | Muskego | 16 | Oconomowoc | 19 | |
| 5 | 9/18/2026 | New Berlin Eisenhower | 23 | Milwaukee Lutheran | 8 | |
| 5 | 9/18/2026 | New Berlin West | 35 | Waukesha South | 0 | |
| 5 | 9/18/2026 | New Holstein | 26 | Kiel | 6 | |
| 5 | 9/18/2026 | New Richmond | 46 | Hudson | 21 | |
| 5 | 9/18/2026 | Northland Pines | 20 | Manawa | 6 | |
| 5 | 9/18/2026 | Oak Creek | 34 | Milwaukee King | 14 | |
| 5 | 9/18/2026 | Oconto | 26 | Southern Door | 0 | |
| 5 | 9/18/2026 | Oconto Falls | 16 | Bonduel | 41 | |
| 5 | 9/18/2026 | Omro | | Lomira | | |
| 5 | 9/18/2026 | Oostburg | | Cedar Grove-Belgium | | |
| 5 | 9/18/2026 | Osceola | 34 | Somerset | 8 | |
| 5 | 9/18/2026 | Oshkosh West | 0 | Neenah | 39 | |
| 5 | 9/18/2026 | Osseo-Fairchild | 22 | Colfax | 8 | |
| 5 | 9/18/2026 | Ozaukee/Random Lake | 0 | Manitowoc Lutheran | 42 | |
| 5 | 9/18/2026 | Peshtigo | 17 | Marinette | 14 | |
| 5 | 9/18/2026 | Pewaukee | 35 | Waukesha North | 7 | |
| 5 | 9/18/2026 | Platteville | | Brodhead/Juda | | |
| 5 | 9/18/2026 | Plymouth | | Nicolet | | |
| 5 | 9/18/2026 | Port Washington | 20 | West Bend West | 12 | |
| 5 | 9/18/2026 | Prairie du Chien | 56 | River Valley | 6 | |
| 5 | 9/18/2026 | Racine Park | | Indian Trail | | |
| 5 | 9/18/2026 | Racine St. Catherine's | | Lake Country Lutheran | | |
| 5 | 9/18/2026 | Reedsburg | 0 | Holmen | 7 | |
| 5 | 9/18/2026 | Reedsville | 31 | Howards Grove | 6 | |
| 5 | 9/18/2026 | Rhinelander | | Antigo | | |
| 5 | 9/18/2026 | Rice Lake | 28 | Menomonie | 34 | |
| 5 | 9/18/2026 | River Falls | 14 | Chippewa Falls | 0 | |
| 5 | 9/18/2026 | Riverdale | 27 | Pecatonica/Argyle | 22 | |
| 5 | 9/18/2026 | Roncalli | | Brillion | | |
| 5 | 9/18/2026 | Royall | | New Lisbon | | |
| 5 | 9/18/2026 | Sauk Prairie | 7 | Edgewood | 21 | |
| 5 | 9/18/2026 | Shawano | 3 | Denmark | 19 | |
| 5 | 9/18/2026 | Spring Valley | 21 | Elmwood/Plum City | 0 | |
| 5 | 9/18/2026 | St. Mary's Springs | 6 | Winnebago Lutheran | 14 | |
| 5 | 9/18/2026 | Stevens Point Area Senior High | 49 | Wausau West | 7 | |
| 5 | 9/18/2026 | Stratford | 28 | Weyauwega-Fremont | 7 | |
| 5 | 9/18/2026 | Sturgeon Bay | 0 | Kewaunee | 51 | |
| 5 | 9/18/2026 | Sun Prairie East | 36 | Sun Prairie West | 0 | |
| 5 | 9/18/2026 | Tomah | | Sparta | | |
| 5 | 9/18/2026 | Two Rivers | | Chilton | | |
| 5 | 9/18/2026 | Valders | 20 | Saint Mary Catholic | 7 | |
| 5 | 9/18/2026 | Verona | 31 | Janesville Parker | 13 | |
| 5 | 9/18/2026 | Viroqua | 6 | Westby | 26 | |
| 5 | 9/18/2026 | Watertown | 12 | Monona Grove | 42 | |
| 5 | 9/18/2026 | Watertown Luther Prep | | Saint Thomas More | | |
| 5 | 9/18/2026 | Waupaca | 0 | Winneconne | 48 | |
| 5 | 9/18/2026 | Waupun | 32 | Adams-Friendship | 6 | |
| 5 | 9/18/2026 | Wausau East | 8 | Medford | 46 | |
| 5 | 9/18/2026 | Wauwatosa East | 21 | Wauwatosa West | 22 | |
| 5 | 9/18/2026 | Wauzeka-Steuben/Seneca | 6 | Black Hawk/Warren (IL) | 54 | |
| 5 | 9/18/2026 | Webster | 36 | Cameron | 0 | |
| 5 | 9/18/2026 | West Allis Hale | | South Milwaukee | | |
| 5 | 9/18/2026 | West Bend East | 0 | Kettle Moraine Lutheran | 42 | |
| 5 | 9/18/2026 | West Salem | | Black River Falls | | |
| 5 | 9/18/2026 | Westosha Central | 6 | Waterford | 20 | |
| 5 | 9/18/2026 | Whitefish Bay | 35 | Slinger | 14 | |
| 5 | 9/18/2026 | Whitehall | 7 | Melrose-Mindoro | 18 | |
| 5 | 9/18/2026 | Wilmot Union | | Union Grove | | |
| 5 | 9/18/2026 | Wisconsin Dells | 14 | Ripon | 22 | |
| 5 | 9/18/2026 | Wisconsin Lutheran | 19 | Menomonee Falls | 20 | |
| 5 | 9/18/2026 | Wrightstown | 6 | Luxemburg-Casco | 24 | |
| 5 | 9/18/2026 | Xavier | 42 | Seymour | 6 | |
| 5 | 9/19/2026 | Cambridge | 39 | Markesan | 22 | |
| 5 | 9/19/2026 | Ithaca/Weston | | Brookwood | | |
| 5 | 9/19/2026 | University School of Milwaukee | | Kingdom Prep Lutheran | | |
| 5 | 9/19/2026 | Milwaukee Academy of Science | | Saint Francis | | |
| 5 | 9/19/2026 | Iola-Scandinavia | 0 | Edgar | 1 | Forfeit |