| Week | Date | Home | Score | Away | Score | |
| 9 | 10/14/2021 | Milwaukee Bay View/Milw Lifelong Learning | 1 | Milwaukee Madison | 0 | Forfeit |
| 9 | 10/14/2021 | Milwaukee Hamilton/Audubon Tech | 24 | Milwaukee Riverside/Golda Meir | 14 | |
| 9 | 10/14/2021 | Milwaukee Vincent/Destiny | 20 | Milwaukee Pulaski/Carmen South/Carmen SE | 30 | |
| 9 | 10/14/2021 | Chetek-Weyerhaeuser | 11 | Barron | 8 | |
| 9 | 10/14/2021 | Dominican | 15 | Catholic Central | 63 | |
| 9 | 10/14/2021 | Hope Christian | 0 | Racine Lutheran | 1 | Forfeit |
| 9 | 10/14/2021 | Kingdom Prep Lutheran | 6 | Racine Lutheran | 49 | |
| 9 | 10/14/2021 | Pulaski | 49 | Manitowoc Lincoln | 0 | |
| 9 | 10/14/2021 | Regis | 1 | Neillsville/Granton | 0 | Forfeit |
| 9 | 10/14/2021 | Riverdale | 28 | Boscobel | 6 | |
| 9 | 10/14/2021 | Whitnall | 42 | Wisconsin Lutheran | 35 | |
| 9 | 10/15/2021 | Osseo-Fairchild | 0 | Fall Creek | 1 | Forfeit |
| 9 | 10/15/2021 | St. John's Northwestern | 0 | Lourdes Academy | 43 | |
| 9 | 10/15/2021 | Kenosha Bradford/Kenosha Reuther | 31 | Racine Horlick | 20 | |
| 9 | 10/15/2021 | Benton/Scales Mound IL/Shullsburg | 0 | Edgar | 42 | |
| 9 | 10/15/2021 | Kenosha Tremper | 19 | Oak Creek | 57 | |
| 9 | 10/15/2021 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 21 | Milwaukee King | 19 | |
| 9 | 10/15/2021 | Milwaukee Reagan | 58 | Milwaukee Bradley Tech/Milw Arts | 27 | |
| 9 | 10/15/2021 | Abbotsford | 14 | Hurley | 54 | |
| 9 | 10/15/2021 | Abbotsford | 1 | Owen-Withee | 0 | Forfeit |
| 9 | 10/15/2021 | Amherst | 28 | Stratford | 14 | |
| 9 | 10/15/2021 | Appleton North | 42 | Oshkosh North | 8 | |
| 9 | 10/15/2021 | Appleton West | 17 | Wisconsin Rapids Lincoln | 31 | |
| 9 | 10/15/2021 | Aquinas | 55 | Gale-Ettrick-Trempealeau | 8 | |
| 9 | 10/15/2021 | Arcadia | 38 | Viroqua | 0 | |
| 9 | 10/15/2021 | Arrowhead | 21 | Oconomowoc | 14 | |
| 9 | 10/15/2021 | Ashland | 18 | Rhinelander | 36 | |
| 9 | 10/15/2021 | Augusta | 28 | Eleva-Strum | 0 | |
| 9 | 10/15/2021 | Badger | 42 | Delavan-Darien | 6 | |
| 9 | 10/15/2021 | Baldwin-Woodville | 19 | Somerset | 30 | |
| 9 | 10/15/2021 | Baraboo | 34 | Portage | 19 | |
| 9 | 10/15/2021 | Bay Port | 39 | Ashwaubenon | 34 | |
| 9 | 10/15/2021 | Benton/Scales Mound IL/Shullsburg | 1 | Southwestern | 0 | Forfeit |
| 9 | 10/15/2021 | Big Foot | 19 | Turner | 49 | |
| 9 | 10/15/2021 | Black Hawk/Warren IL | 0 | River Ridge | 25 | |
| 9 | 10/15/2021 | Black River Falls | 27 | Altoona | 39 | |
| 9 | 10/15/2021 | Blair-Taylor | 46 | Cochrane-Fountain City | 8 | |
| 9 | 10/15/2021 | Bloomer | 14 | Spooner | 43 | |
| 9 | 10/15/2021 | Brookfield Academy | 35 | Kenosha Christian Life | 21 | |
| 9 | 10/15/2021 | Brookfield Central | 42 | Menomonee Falls | 28 | |
| 9 | 10/15/2021 | Brookwood | 6 | Luther | 35 | |
| 9 | 10/15/2021 | Brown Deer | 6 | University School of Milwaukee | 26 | |
| 9 | 10/15/2021 | Burlington | 9 | Waterford | 7 | |
| 9 | 10/15/2021 | Cadott | 28 | Spring Valley | 6 | |
| 9 | 10/15/2021 | Cambria-Friesland | 0 | Fall River/Rio | 32 | |
| 9 | 10/15/2021 | Cambridge | 6 | Clinton | 48 | |
| 9 | 10/15/2021 | Cameron | 8 | St. Croix Falls | 49 | |
| 9 | 10/15/2021 | Campbellsport | 18 | Mayville | 13 | |
| 9 | 10/15/2021 | Cashton | 13 | Bangor | 17 | |
| 9 | 10/15/2021 | Catholic Memorial | 64 | Pius XI Catholic | 14 | |
| 9 | 10/15/2021 | Cedarburg | 21 | West Bend East | 14 | |
| 9 | 10/15/2021 | Chilton | 41 | Valders | 22 | |
| 9 | 10/15/2021 | Clear Lake | 0 | Boyceville | 29 | |
| 9 | 10/15/2021 | Colby | 54 | Auburndale | 7 | |
| 9 | 10/15/2021 | Coleman | 58 | Menominee Indian | 0 | |
| 9 | 10/15/2021 | Columbus | 49 | Lakeside Lutheran | 21 | |
| 9 | 10/15/2021 | Crivitz | 39 | Crandon | 24 | |
| 9 | 10/15/2021 | Cuba City | 64 | Parkview/Albany | 13 | |
| 9 | 10/15/2021 | Darlington | 46 | Lancaster | 26 | |
| 9 | 10/15/2021 | De Pere | 35 | Green Bay Preble | 7 | |
| 9 | 10/15/2021 | Durand | 36 | Mondovi | 28 | |
| 9 | 10/15/2021 | Eau Claire North | 14 | Eau Claire Memorial | 28 | |
| 9 | 10/15/2021 | Edgewood | 31 | Monroe | 28 | |
| 9 | 10/15/2021 | Elk Mound | 21 | Stanley-Boyd | 27 | |
| 9 | 10/15/2021 | Elkhorn Area | 7 | Union Grove | 35 | |
| 9 | 10/15/2021 | Ellsworth | 57 | Amery | 0 | |
| 9 | 10/15/2021 | Elmwood/Plum City | 14 | Turtle Lake | 46 | |
| 9 | 10/15/2021 | Fall Creek | 19 | Iowa-Grant | 18 | |
| 9 | 10/15/2021 | Fennimore | 8 | Potosi/Cassville | 40 | |
| 9 | 10/15/2021 | Flambeau | 0 | Hurley | 1 | Forfeit |
| 9 | 10/15/2021 | Fox Valley Lutheran | 0 | Shawano | 34 | |
| 9 | 10/15/2021 | Franklin | 76 | Racine Case | 0 | |
| 9 | 10/15/2021 | Freedom | 26 | Wrightstown | 14 | |
| 9 | 10/15/2021 | Glenwood City | 55 | Colfax | 0 | |
| 9 | 10/15/2021 | Grafton | 62 | Cudahy | 0 | |
| 9 | 10/15/2021 | Greendale | 31 | Greenfield | 7 | |
| 9 | 10/15/2021 | Hamilton | 35 | Brookfield East | 28 | |
| 9 | 10/15/2021 | Hayward/Lac Courte Oreilles | 28 | Lakeland | 20 | |
| 9 | 10/15/2021 | Hilbert | 42 | Oostburg | 8 | |
| 9 | 10/15/2021 | Holmen | 21 | West Salem | 28 | |
| 9 | 10/15/2021 | Hortonville | 22 | Wausau West | 30 | |
| 9 | 10/15/2021 | Hudson | 14 | Chippewa Falls | 20 | |
| 9 | 10/15/2021 | Iowa-Grant | 1 | Pecatonica/Argyle | 0 | Forfeit |
| 9 | 10/15/2021 | Ithaca | 46 | Hillsboro | 18 | |
| 9 | 10/15/2021 | Janesville Parker | 35 | DeForest | 48 | |
| 9 | 10/15/2021 | Jefferson | 42 | East Troy | 0 | |
| 9 | 10/15/2021 | Johnson Creek | 28 | Deerfield | 22 | |
| 9 | 10/15/2021 | Kaukauna | 17 | Kimberly | 56 | |
| 9 | 10/15/2021 | Kenosha St. Joseph Catholic | 56 | Living Word Lutheran | 18 | |
| 9 | 10/15/2021 | Kettle Moraine | 63 | Waukesha South | 21 | |
| 9 | 10/15/2021 | Kettle Moraine Lutheran | 55 | Waupun | 0 | |
| 9 | 10/15/2021 | Kewaunee | 33 | Southern Door | 0 | |
| 9 | 10/15/2021 | Kohler/Sheboygan Christian/Sheboygan Lutheran | 18 | Brillion | 21 | |
| 9 | 10/15/2021 | La Crosse Central | 42 | La Crosse Logan | 20 | |
| 9 | 10/15/2021 | Laconia | 14 | St. Mary's Springs | 24 | |
| 9 | 10/15/2021 | Lake Holcombe | 0 | Webster | 1 | Forfeit |
| 9 | 10/15/2021 | Lake Mills | 35 | Horicon/Hustisford | 0 | |
| 9 | 10/15/2021 | Little Chute | 15 | Menominee (MI) | 6 | |
| 9 | 10/15/2021 | Lodi | 38 | Watertown Luther Prep | 0 | |
| 9 | 10/15/2021 | Loyal | 14 | Assumption | 49 | |
| 9 | 10/15/2021 | Luxemburg-Casco | 42 | Denmark | 21 | |
| 9 | 10/15/2021 | Madison East | 6 | Middleton | 47 | |
| 9 | 10/15/2021 | Madison West | 21 | Madison La Follette | 22 | |
| 9 | 10/15/2021 | Manawa | 14 | Weyauwega-Fremont | 21 | |
| 9 | 10/15/2021 | Marathon | 1 | Athens | 0 | Forfeit |
| 9 | 10/15/2021 | Markesan | 22 | Marshall | 33 | |
| 9 | 10/15/2021 | Marquette | 62 | West Allis Hale | 35 | |
| 9 | 10/15/2021 | Marshfield | 6 | Stevens Point | 29 | |
| 9 | 10/15/2021 | Mauston | 32 | Wisconsin Dells | 40 | |
| 9 | 10/15/2021 | McFarland | 28 | Edgerton | 7 | |
| 9 | 10/15/2021 | Melrose-Mindoro | 20 | Pepin/Alma | 39 | |
| 9 | 10/15/2021 | Menasha | 49 | Green Bay East | 0 | |
| 9 | 10/15/2021 | Menomonie | 42 | Superior | 14 | |
| 9 | 10/15/2021 | Merrill | 12 | Medford | 30 | |
| 9 | 10/15/2021 | Milton | 42 | Janesville Craig | 15 | |
| 9 | 10/15/2021 | Mineral Point | 7 | Belleville | 35 | |
| 9 | 10/15/2021 | Monona Grove | 6 | Fort Atkinson | 7 | |
| 9 | 10/15/2021 | Montello/Green Lake/Princeton | 8 | Westfield | 42 | |
| 9 | 10/15/2021 | Mosinee | 1 | Antigo | 0 | Forfeit |
| 9 | 10/15/2021 | Mount Horeb/Barneveld | 20 | Reedsburg | 13 | |
| 9 | 10/15/2021 | Neenah | 40 | Appleton East | 0 | |
| 9 | 10/15/2021 | New Berlin Eisenhower | 40 | Wauwatosa East | 24 | |
| 9 | 10/15/2021 | New Glarus/Monticello | 40 | Dodgeville | 0 | |
| 9 | 10/15/2021 | New Lisbon | 42 | Necedah | 38 | |
| 9 | 10/15/2021 | New London | 44 | Marinette | 20 | |
| 9 | 10/15/2021 | New Richmond | 28 | Rice Lake | 44 | |
| 9 | 10/15/2021 | Nicolet | 20 | Homestead | 35 | |
| 9 | 10/15/2021 | Northland Pines | 0 | Niagara/Goodman/Pembine | 1 | Forfeit |
| 9 | 10/15/2021 | Northwestern | 56 | Cumberland | 30 | |
| 9 | 10/15/2021 | Notre Dame | 30 | Sheboygan South | 0 | |
| 9 | 10/15/2021 | Oconto | 14 | Clintonville | 18 | |
| 9 | 10/15/2021 | Oconto Falls | 38 | Tomahawk | 23 | |
| 9 | 10/15/2021 | Omro | 63 | North Fond du Lac | 6 | |
| 9 | 10/15/2021 | Osceola | 28 | Prescott | 21 | |
| 9 | 10/15/2021 | Oshkosh West | 13 | Fond du Lac | 14 | |
| 9 | 10/15/2021 | Ozaukee | 31 | Howards Grove | 22 | |
| 9 | 10/15/2021 | Palmyra-Eagle | 21 | Dodgeland | 29 | |
| 9 | 10/15/2021 | Pardeeville | 29 | Waterloo | 44 | |
| 9 | 10/15/2021 | Peshtigo | 0 | Bonduel | 34 | |
| 9 | 10/15/2021 | Pewaukee | 49 | Milwaukee Lutheran | 0 | |
| 9 | 10/15/2021 | Pittsville | 22 | Iola-Scandinavia | 41 | |
| 9 | 10/15/2021 | Platteville | 19 | Adams-Friendship | 42 | |
| 9 | 10/15/2021 | Plymouth | 28 | Berlin | 14 | |
| 9 | 10/15/2021 | Port Washington | 34 | Kewaskum | 13 | |
| 9 | 10/15/2021 | Prairie du Chien | 19 | Brodhead/Juda | 22 | |
| 9 | 10/15/2021 | Racine Park | 42 | Kenosha Indian Trail | 34 | |
| 9 | 10/15/2021 | Racine Saint Catherine’s | 36 | Saint Francis | 23 | |
| 9 | 10/15/2021 | Randolph | 41 | Mishicot | 0 | |
| 9 | 10/15/2021 | Random Lake | 0 | Cedar Grove-Belgium | 56 | |
| 9 | 10/15/2021 | Reedsville | 49 | Manitowoc Lutheran | 19 | |
| 9 | 10/15/2021 | Rib Lake/Prentice | 35 | Ladysmith | 7 | |
| 9 | 10/15/2021 | Richland Center | 10 | River Valley | 7 | |
| 9 | 10/15/2021 | Ripon | 7 | Sheboygan Falls | 21 | |
| 9 | 10/15/2021 | Roncalli | 8 | Kiel | 56 | |
| 9 | 10/15/2021 | Rosholt | 8 | Marathon | 32 | |
| 9 | 10/15/2021 | Rosholt | 1 | Almond-Bancroft | 0 | Forfeit |
| 9 | 10/15/2021 | Royall | 6 | De Soto | 12 | |
| 9 | 10/15/2021 | Saint Thomas More | 7 | Martin Luther | 33 | |
| 9 | 10/15/2021 | Seymour | 6 | Waupaca | 26 | |
| 9 | 10/15/2021 | Sheboygan North | 64 | Green Bay West | 6 | |
| 9 | 10/15/2021 | Shoreland Lutheran | 6 | Lake Country Lutheran | 56 | |
| 9 | 10/15/2021 | South Milwaukee | 34 | Shorewood/Messmer | 12 | |
| 9 | 10/15/2021 | Sparta | 14 | River Falls | 43 | |
| 9 | 10/15/2021 | Spencer/Columbus Catholic | 17 | Shiocton | 6 | |
| 9 | 10/15/2021 | Stoughton | 35 | Sauk Prairie | 0 | |
| 9 | 10/15/2021 | Sturgeon Bay | 0 | Mishicot | 1 | Forfeit |
| 9 | 10/15/2021 | Thorp | 0 | Edgar | 1 | Forfeit |
| 9 | 10/15/2021 | Tomah | 13 | Onalaska | 51 | |
| 9 | 10/15/2021 | Two Rivers | 20 | New Holstein | 14 | |
| 9 | 10/15/2021 | Unity | 26 | Grantsburg | 20 | |
| 9 | 10/15/2021 | Verona | 35 | Sun Prairie | 38 | 1OT |
| 9 | 10/15/2021 | Watertown | 0 | Oregon | 10 | |
| 9 | 10/15/2021 | Waukesha North | 7 | Muskego | 56 | |
| 9 | 10/15/2021 | Waukesha West | 33 | Mukwonago | 35 | |
| 9 | 10/15/2021 | Waunakee | 50 | Beaver Dam | 12 | |
| 9 | 10/15/2021 | Wausau East | 0 | D.C. Everest | 1 | Forfeit |
| 9 | 10/15/2021 | Wautoma | 18 | Poynette | 28 | |
| 9 | 10/15/2021 | Wauwatosa West | 54 | New Berlin West | 0 | |
| 9 | 10/15/2021 | Wauzeka-Steuben/Seneca | 8 | Highland | 44 | |
| 9 | 10/15/2021 | Wayland Academy | 0 | Randolph | 1 | |
| 9 | 10/15/2021 | West Allis Central | 0 | Germantown | 1 | Forfeit |
| 9 | 10/15/2021 | West Bend West | 20 | Hartford Union | 48 | |
| 9 | 10/15/2021 | West De Pere | 55 | Green Bay Southwest | 14 | |
| 9 | 10/15/2021 | Westby | 8 | St. Croix Central | 28 | |
| 9 | 10/15/2021 | Whitefish Bay | 21 | Slinger | 14 | |
| 9 | 10/15/2021 | Whitehall | 40 | Independence/Gilmanton | 14 | |
| 9 | 10/15/2021 | Whitewater | 0 | Evansville | 42 | |
| 9 | 10/15/2021 | Wild Rose | 0 | Pacelli | 62 | |
| 9 | 10/15/2021 | Wilmot Union | 35 | Westosha Central | 14 | |
| 9 | 10/15/2021 | Winnebago Lutheran Academy | 21 | Lomira | 14 | |
| 9 | 10/15/2021 | Winneconne | 0 | Xavier | 13 | |
| 9 | 10/15/2021 | Wittenberg-Birnamwood | 79 | Nekoosa | 8 | |
| 9 | 10/15/2021 | Beloit Memorial | 14 | Madison Memorial | 17 | |