| Week | Date | Home | Score | Away | Score | |
| 8 | 10/10/2025 | Monticello | 8 | Belmont | 57 | |
| 8 | 10/10/2025 | Wayland Academy | 16 | Princeton/Green Lake | 36 | |
| 8 | 10/10/2025 | Menominee Nation | 0 | Port Edwards | 1 | Forfeit |
| 8 | 10/10/2025 | South Shore | 0 | Chequamegon/Butternut/Mercer | 1 | Forfeit |
| 8 | 10/10/2025 | St. John's Northwestern | 8 | Oakfield | 57 | |
| 8 | 10/10/2025 | Algoma | 48 | Suring | 18 | |
| 8 | 10/10/2025 | Alma Center Lincoln | 52 | Cornell | 0 | |
| 8 | 10/10/2025 | Almond-Bancroft | 1 | Bowler/Gresham | 0 | Forfeit |
| 8 | 10/10/2025 | Athens | 1 | Rib Lake | 0 | |
| 8 | 10/10/2025 | Bruce | 50 | Winter/Birchwood | 14 | |
| 8 | 10/10/2025 | Clayton | 34 | Owen-Withee | 68 | |
| 8 | 10/10/2025 | De Soto | 44 | Highland | 14 | |
| 8 | 10/10/2025 | Elkhart Lake-Glenbeulah | 41 | Williams Bay | 12 | |
| 8 | 10/10/2025 | Faith Christian | 0 | Elcho/White Lake | 1 | |
| 8 | 10/10/2025 | Flambeau | 24 | Prentice | 0 | |
| 8 | 10/10/2025 | Florence | 16 | Niagara | 24 | |
| 8 | 10/10/2025 | Frederic | 1 | Valley Christian (Osceola) | 0 | |
| 8 | 10/10/2025 | Gibraltar | 6 | Lena/Saint Thomas Aquinas | 43 | |
| 8 | 10/10/2025 | Green Bay N.E.W. Lutheran/Oneida Nation/Providence Academy (Green Bay) | 59 | Gillett | 6 | |
| 8 | 10/10/2025 | Hurley | 6 | Phillips | 54 | |
| 8 | 10/10/2025 | Lake Holcombe | 0 | Gilman | 69 | |
| 8 | 10/10/2025 | New Auburn | 34 | Siren | 22 | |
| 8 | 10/10/2025 | North Crawford | 55 | Kickapoo/La Farge | 8 | |
| 8 | 10/10/2025 | Northwood/Solon Springs | 6 | Shell Lake | 26 | |
| 8 | 10/10/2025 | Prairie Farm | 46 | Luck | 6 | |
| 8 | 10/10/2025 | Sevastopol | 66 | Rosholt | 24 | |
| 8 | 10/10/2025 | South Beloit, IL | 38 | Abundant Life Christian/Saint Ambrose | 8 | |
| 8 | 10/10/2025 | Thorp | 6 | McDonell Central Catholic | 66 | |
| 8 | 10/10/2025 | Three Lakes/Phelps | 45 | Wausaukee | 12 | |
| 8 | 10/10/2025 | Tri-County | 34 | Newman Catholic | 12 | |
| 8 | 10/10/2025 | Valley Christian (Oshkosh) | 53 | Montello | 6 | |
| 8 | 10/10/2025 | Wabeno/Laona | 56 | Almond-Bancroft | 6 | |
| 8 | 10/10/2025 | Wabeno/Laona | 1 | Pembine/Goodman | 0 | Forfeit |
| 8 | 10/10/2025 | Washburn | 7 | Frederic | 55 | |
| 8 | 10/10/2025 | Washburn | 1 | Mellen | 0 | |
| 8 | 10/10/2025 | Wild Rose | 16 | Marion/Tigerton | 51 | |
| 8 | 10/10/2025 | Wisconsin Heights | 12 | Wonewoc-Center/Weston | 70 | |