| Week | Date | Home | Score | Away | Score | |
| 5 | 9/18/2025 | Bowler/Gresham | | Port Edwards | | |
| 5 | 9/19/2025 | Gilman | | McDonell Central Catholic | | |
| 5 | 9/19/2025 | Mellen | | Shell Lake | | |
| 5 | 9/19/2025 | Menominee Nation | | Wild Rose | | |
| 5 | 9/19/2025 | Monticello | | North Crawford | | |
| 5 | 9/19/2025 | Port Edwards | | Wausaukee | | |
| 5 | 9/19/2025 | South Shore | | Northwood/Solon Springs | | |
| 5 | 9/19/2025 | Almond-Bancroft | | Tri-County | | |
| 5 | 9/19/2025 | Belmont | | Wonewoc-Center/Weston | | |
| 5 | 9/19/2025 | Chequamegon/Butternut/Mercer | | Flambeau | | |
| 5 | 9/19/2025 | Cornell | | Siren | | |
| 5 | 9/19/2025 | Florence | | Wabeno/Laona | | |
| 5 | 9/19/2025 | Frederic | | Luck | | |
| 5 | 9/19/2025 | Gillett | | Lena/Saint Thomas Aquinas | | |
| 5 | 9/19/2025 | Green Bay N.E.W. Lutheran/Oneida Nation/Providence Academy (Green Bay) | | Algoma | | |
| 5 | 9/19/2025 | Highland | | Kickapoo/La Farge | | |
| 5 | 9/19/2025 | Hurley | | Athens | | |
| 5 | 9/19/2025 | Lake Holcombe | | Alma Center Lincoln | | |
| 5 | 9/19/2025 | Marion/Tigerton | | Newman Catholic | | |
| 5 | 9/19/2025 | Niagara | | Suring | | |
| 5 | 9/19/2025 | Phillips | | Prentice | | |
| 5 | 9/19/2025 | Princeton/Green Lake | | Montello | | |
| 5 | 9/19/2025 | Rib Lake | | Winter/Birchwood | | |
| 5 | 9/19/2025 | Sevastopol | | Gibraltar | | |
| 5 | 9/19/2025 | Shell Lake | | New Auburn | | |
| 5 | 9/19/2025 | Three Lakes/Phelps | | Elcho/White Lake | | |
| 5 | 9/19/2025 | Valley Christian (Oshkosh) | | Elkhart Lake-Glenbeulah | | |
| 5 | 9/19/2025 | Washburn | | Bruce | | |
| 5 | 9/19/2025 | Williams Bay | | Oakfield | | |
| 5 | 9/19/2025 | Wisconsin Heights | | De Soto | | |
| 5 | 9/19/2025 | Aldon Hebron, IL | | Abundant Life Christian/Saint Ambrose | | |
| 5 | 9/19/2025 | Valley Christian (Osceola) | | New Auburn | | |
| 5 | 9/20/2025 | Pembine/Goodman | | Wausaukee | | |
| 5 | 9/20/2025 | Wayland Academy | | St. John's Northwestern | | |
| 5 | 9/20/2025 | Clayton | | Prairie Farm | | |