| Date | Week | Home | Score | Away | Score | |
| 8/22/2025 | 1 | Hillsboro (NC) | 48 | Boscobel | 7 | |
| 8/29/2025 | 2 | Boscobel | 0 | Southwestern/East Dubuque, IL (NC) | 48 | |
| 9/5/2025 | 3 | Boscobel | 28 | Pecatonica/Argyle | 50 | |
| 9/13/2025 | 4 | Black Hawk/Warren, IL | 74 | Boscobel | 0 | |
| 9/19/2025 | 5 | Boscobel | | Potosi/Cassville | | |
| 9/19/2025 | 5 | Boscobel | | Potosi/Cassville (NC) | | |
| 9/26/2025 | 6 | River Ridge (NC) | | Boscobel | | |
| 9/26/2025 | 6 | River Ridge | | Boscobel | | |
| 10/3/2025 | 7 | Riverdale (NC) | | Boscobel | | |
| 10/3/2025 | 7 | Riverdale (NC) | | Boscobel | | |
| 10/10/2025 | 8 | Boscobel | | Iowa-Grant (NC) | | |
| 10/10/2025 | 8 | Boscobel | | Iowa-Grant | | |
| 10/17/2025 | 9 | Wauzeka-Steuben/Seneca (NC) | | Boscobel | | |
| 10/17/2025 | 9 | Wauzeka-Steuben/Seneca | | Boscobel | | |