| Date | Week | Home | Score | Away | Score | |
| 8/22/2025 | 1 | Stanley-Boyd (NC) | 12 | Colby | 29 | |
| 8/29/2025 | 2 | Abbotsford (NC) | 27 | Colby | 14 | |
| 9/5/2025 | 3 | Colby | 8 | Amherst | 38 | |
| 9/12/2025 | 4 | Loyal/Greenwood | 32 | Colby | 6 | |
| 9/19/2025 | 5 | Colby | 0 | Marathon | 40 | |
| 9/27/2025 | 6 | Stratford | | Colby | | |
| 9/27/2025 | 6 | Stratford | 57 | Colby | 0 | |
| 10/3/2025 | 7 | Colby | 33 | Wittenberg-Birnamwood | 52 | |
| 10/10/2025 | 8 | Spencer/Columbus Catholic | | Colby | | |
| 10/10/2025 | 8 | Spencer/Columbus Catholic | 43 | Colby | 12 | |
| 10/17/2025 | 9 | Colby | | Weyauwega-Fremont | | |
| 10/17/2025 | 9 | Colby | 14 | Weyauwega-Fremont | 22 | |