| Date | Week | Home | Score | Away | Score | |
| 8/22/2025 | 1 | Ithaca | 21 | Riverdale (NC) | 18 | |
| 8/29/2025 | 2 | Wauzeka-Steuben/Seneca (NC) | 44 | Ithaca | 14 | |
| 9/5/2025 | 3 | Ithaca | 26 | Hillsboro | 21 | |
| 9/12/2025 | 4 | Bangor | 16 | Ithaca | 8 | |
| 9/19/2025 | 5 | Ithaca | | Cashton | | |
| 9/19/2025 | 5 | Ithaca | 6 | Cashton | 20 | |
| 9/26/2025 | 6 | Necedah | | Ithaca | | |
| 9/26/2025 | 6 | Necedah | 14 | Ithaca | 43 | |
| 10/3/2025 | 7 | Ithaca | 20 | Royall | 0 | |
| 10/4/2025 | 7 | Ithaca | | Royall | | |
| 10/10/2025 | 8 | Brookwood | 13 | Ithaca | 12 | |
| 10/10/2025 | 8 | Brookwood | | Ithaca | | |
| 10/17/2025 | 9 | New Lisbon | | Ithaca | | |
| 10/17/2025 | 9 | New Lisbon | 6 | Ithaca | 35 | |