| Date | Week | Home | Score | Away | Score | |
| 8/22/2025 | 1 | Milwaukee Reagan | 44 | Saint Francis (NC) | 7 | |
| 8/29/2025 | 2 | Milwaukee Reagan | 6 | New Berlin West (NC) | 19 | |
| 9/5/2025 | 3 | Milwaukee Reagan | 50 | Milwaukee Marshall/Carmen Northwest/Milwaukee Juneau/Milwaukee School of Languages | 12 | |
| 9/12/2025 | 4 | Milwaukee Reagan | 38 | Milwaukee Bradley Tech/Milwaukee Arts | 8 | |
| 9/19/2025 | 5 | Milwaukee Reagan | | Milwaukee King | | |
| 9/19/2025 | 5 | Milwaukee King | 34 | Milwaukee Reagan | 36 | |
| 9/26/2025 | 6 | Milwaukee Hamilton/Audubon Technology | 28 | Milwaukee Reagan | 36 | |
| 9/26/2025 | 6 | Milwaukee Hamilton/Audubon Technology | | Milwaukee Reagan | | |
| 10/3/2025 | 7 | Milwaukee Riverside/Golda Meir | | Milwaukee Reagan | | |
| 10/3/2025 | 7 | Milwaukee Riverside/Golda Meir | 6 | Milwaukee Reagan | 40 | |
| 10/10/2025 | 8 | Milwaukee Reagan | | Milwaukee Pulaski/Carmen South/Carmen Southeast | | |
| 10/10/2025 | 8 | Milwaukee Reagan | 40 | Milwaukee Pulaski/Carmen South/Carmen Southeast | 0 | |
| 10/17/2025 | 9 | Milwaukee Reagan | | Milwaukee North/Milwaukee WI Conservatory of Lifelong Learning | | |
| 10/17/2025 | 9 | Milwaukee Reagan | 58 | Milwaukee North/Milwaukee WI Conservatory of Lifelong Learning | 14 | |