| Date | Week | Home | Score | Away | Score | |
| 8/21/2025 | 1 | Living Word Lutheran (NC) | 14 | Lourdes Academy | 42 | |
| 8/28/2025 | 2 | Lourdes Academy | 22 | Reedsville (NC) | 13 | |
| 9/5/2025 | 3 | Lourdes Academy | 49 | Randolph | 14 | |
| 9/12/2025 | 4 | Johnson Creek | 12 | Lourdes Academy | 36 | |
| 9/19/2025 | 5 | Lourdes Academy | | Cambria-Friesland | | |
| 9/19/2025 | 5 | Lourdes Academy | 24 | Cambria-Friesland | 14 | |
| 9/26/2025 | 6 | Westfield | | Lourdes Academy | | |
| 9/26/2025 | 6 | Westfield | 6 | Lourdes Academy | 23 | |
| 10/3/2025 | 7 | Lourdes Academy | | Dodgeland | | |
| 10/3/2025 | 7 | Lourdes Academy | 45 | Dodgeland | 8 | |
| 10/10/2025 | 8 | Lourdes Academy | 42 | Palmyra-Eagle | 0 | |
| 10/10/2025 | 8 | Lourdes Academy | | Palmyra-Eagle | | |
| 10/17/2025 | 9 | Parkview/Albany | | Lourdes Academy | | |
| 10/17/2025 | 9 | Parkview/Albany | 0 | Lourdes Academy | 38 | |