| Date | Week | Home | Score | Away | Score | |
| 8/23/2019 | 1 | De Soto | 40 | Wonewoc-Center/Weston | 6 | |
| 8/30/2019 | 2 | Riverdale | 0 | De Soto | 28 | |
| 9/6/2019 | 3 | De Soto | 55 | Kickapoo/La Farge | 6 | |
| 9/13/2019 | 4 | De Soto | 23 | Highland | 6 | |
| 9/20/2019 | 5 | Royall (NC) | 0 | De Soto | 21 | |
| 9/27/2019 | 6 | De Soto | 13 | Wauzeka-Steuben/Seneca | 14 | 1OT |
| 10/4/2019 | 7 | North Crawford | 0 | De Soto | 53 | |
| 10/11/2019 | 8 | Ithaca | 22 | De Soto | 20 | |
| 10/18/2019 | 9 | De Soto | 41 | Kenosha Christian Life (NC) | 0 | |