| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Pecatonica/Argyle | 6 | Waterloo (NC) | 22 | |
| 8/27/2021 | 2 | Pecatonica/Argyle | 30 | Parkview/Albany (NC) | 0 | |
| 9/3/2021 | 3 | Belleville | 62 | Pecatonica/Argyle | 0 | |
| 9/10/2021 | 4 | Pecatonica/Argyle | 8 | River Ridge | 46 | |
| 9/18/2021 | 5 | Pecatonica/Argyle | 12 | Black Hawk/Warren, IL | 46 | |
| 9/24/2021 | 6 | Potosi/Cassville | 57 | Pecatonica/Argyle | 0 | |
| 10/1/2021 | 7 | Benton/Scales Mound IL/Shullsburg | 43 | Pecatonica/Argyle | 8 | |
| 10/9/2021 | 8 | Pecatonica/Argyle | 1 | Southwestern/East Dubuque, IL | 0 | |
| 10/15/2021 | 9 | Iowa-Grant | 1 | Pecatonica/Argyle | 0 | |