| Date | Week | Home | Score | Away | Score | |
| 8/19/2021 | 1 | Racine Saint Catherine’s (NC) | 30 | Mount Horeb/Barneveld | 37 | |
| 8/27/2021 | 2 | Mount Horeb/Barneveld | 29 | Monroe (NC) | 28 | |
| 9/3/2021 | 3 | Sauk Prairie | 0 | Mount Horeb/Barneveld | 35 | |
| 9/10/2021 | 4 | Mount Horeb/Barneveld | 29 | Portage | 26 | |
| 9/18/2021 | 5 | Baraboo | 14 | Mount Horeb/Barneveld | 13 | |
| 9/24/2021 | 6 | Mount Horeb/Barneveld | 20 | Stoughton | 8 | |
| 10/1/2021 | 7 | Monona Grove | 24 | Mount Horeb/Barneveld | 26 | |
| 10/8/2021 | 8 | Fort Atkinson | 12 | Mount Horeb/Barneveld | 18 | |
| 10/15/2021 | 9 | Mount Horeb/Barneveld | 20 | Reedsburg | 13 | |