Central Wisconsin - Small
| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | De Soto (NC) | 34 | Assumption | 31 | |
| 8/28/2021 | 2 | Assumption | 22 | Auburndale (NC) | 18 | |
| 9/3/2021 | 3 | Assumption | 46 | Wild Rose | 0 | |
| 9/10/2021 | 4 | Pacelli | 49 | Assumption | 20 | |
| 9/17/2021 | 5 | Assumption | 34 | Iola-Scandinavia | 42 | |
| 9/23/2021 | 6 | Assumption | 39 | Pittsville | 0 | |
| 10/1/2021 | 7 | Rosholt | 6 | Assumption | 56 | |
| 10/8/2021 | 8 | Assumption | 1 | Almond-Bancroft | 0 | |
| 10/9/2021 | 8 | *Assumption | 7 | *Webster (NC) | 26 | |
| 10/15/2021 | 9 | Loyal | 14 | Assumption | 49 | |
* Denotes the game does not count towards playoff calculation for the team (exhibition only)