| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Milwaukee Lutheran | 6 | Grafton (NC) | 41 | |
| 8/27/2021 | 2 | Milwaukee Lutheran | 36 | Kingdom Prep Lutheran (NC) | 22 | |
| 9/3/2021 | 3 | Wauwatosa East | 38 | Milwaukee Lutheran | 28 | |
| 9/10/2021 | 4 | Milwaukee Lutheran | 6 | Wauwatosa West | 72 | |
| 9/17/2021 | 5 | Pius XI Catholic | 12 | Milwaukee Lutheran | 24 | |
| 9/24/2021 | 6 | Milwaukee Lutheran | 6 | New Berlin West | 36 | |
| 10/1/2021 | 7 | Catholic Memorial | 2 | Milwaukee Lutheran | 0 | |
| 10/8/2021 | 8 | Milwaukee Lutheran | 6 | New Berlin Eisenhower | 48 | |
| 10/15/2021 | 9 | Pewaukee | 49 | Milwaukee Lutheran | 0 | |