| Date | Week | Home | Score | Away | Score | |
| 8/19/2021 | 1 | Coleman (NC) | 38 | Peshtigo | 12 | |
| 8/27/2021 | 2 | Peshtigo | 47 | Niagara/Goodman/Pembine (NC) | 8 | |
| 9/3/2021 | 3 | Peshtigo | 20 | Kewaunee | 28 | |
| 9/10/2021 | 4 | Peshtigo | 0 | Oconto | 1 | |
| 9/17/2021 | 5 | Peshtigo | 0 | Mishicot | 1 | |
| 9/24/2021 | 6 | Sturgeon Bay | 0 | Peshtigo | 1 | |
| 9/24/2021 | 6 | *Lourdes Academy (NC) | 42 | *Peshtigo | 0 | |
| 10/1/2021 | 7 | Peshtigo | 0 | Southern Door | 1 | |
| 10/8/2021 | 8 | Clintonville | 1 | Peshtigo | 0 | |
| 10/15/2021 | 9 | Peshtigo | 0 | Bonduel | 34 | |