| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Kenosha Bradford/Kenosha Reuther (NC) | 10 | Regis | 27 | |
| 8/28/2021 | 2 | Regis | 49 | Bloomer (NC) | 0 | |
| 9/2/2021 | 3 | Osseo-Fairchild | 0 | Regis | 42 | |
| 9/10/2021 | 4 | Elk Mound | 6 | Regis | 43 | |
| 9/16/2021 | 5 | Regis | 36 | Durand | 26 | |
| 9/24/2021 | 6 | Fall Creek | 0 | Regis | 50 | |
| 10/2/2021 | 7 | Regis | 28 | Mondovi | 20 | |
| 10/8/2021 | 8 | Stanley-Boyd | 19 | Regis | 27 | |
| 10/14/2021 | 9 | Regis | 1 | Neillsville/Granton | 0 | |