| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Riverdale | 14 | Southwestern/East Dubuque, IL (NC) | 22 | |
| 8/27/2021 | 2 | Iowa-Grant (NC) | 26 | Riverdale | 14 | |
| 9/3/2021 | 3 | De Soto | 40 | Riverdale | 0 | |
| 9/10/2021 | 4 | Riverdale | 34 | Hillsboro | 36 | |
| 9/17/2021 | 5 | Wauzeka-Steuben/Seneca | 10 | Riverdale | 0 | |
| 9/24/2021 | 6 | Riverdale | 6 | Highland | 52 | |
| 10/1/2021 | 7 | Riverdale | 14 | Ithaca | 40 | |
| 10/8/2021 | 8 | New Lisbon | 44 | Riverdale | 18 | |
| 10/14/2021 | 9 | Riverdale | 28 | Boscobel | 6 | |