| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Cudahy (NC) | 0 | Milwaukee Academy of Science | 60 | |
| 8/27/2022 | 2 | West Allis Central (NC) | 6 | Milwaukee Academy of Science | 36 | |
| 9/17/2022 | 5 | *Living Word Lutheran (NC) | 0 | Milwaukee Academy of Science | 34 | |
| 9/24/2022 | 6 | Menominee (MI) (NC) | 48 | Milwaukee Academy of Science | 36 | |
| 9/30/2022 | 7 | *Stevens Point Area Senior High (NC) | 45 | Milwaukee Academy of Science | 24 | |
| 10/7/2022 | 8 | Wisconsin Lutheran (NC) | 29 | Milwaukee Academy of Science | 6 | |
| 10/14/2022 | 9 | Milwaukee Academy of Science | 36 | Milwaukee Excellence Charter School (NC) | 0 | |