| Date | Week | Home | Score | Away | Score | |
| 8/20/2021 | 1 | Black Hawk/Warren, IL | 20 | Westby (NC) | 13 | |
| 8/27/2021 | 2 | Black Hawk/Warren, IL | 14 | Marshall (NC) | 28 | |
| 9/3/2021 | 3 | Black Hawk/Warren, IL | 56 | Iowa-Grant | 0 | |
| 9/10/2021 | 4 | Mineral Point | 22 | Black Hawk/Warren, IL | 16 | |
| 9/18/2021 | 5 | Pecatonica/Argyle | 12 | Black Hawk/Warren, IL | 46 | |
| 9/24/2021 | 6 | Southwestern/East Dubuque, IL | 0 | Black Hawk/Warren, IL | 54 | |
| 10/2/2021 | 7 | Black Hawk/Warren, IL | 24 | Potosi/Cassville | 11 | |
| 10/8/2021 | 8 | Black Hawk/Warren, IL | 1 | Benton/Scales Mound IL/Shullsburg | 0 | |
| 10/15/2021 | 9 | Black Hawk/Warren, IL | 0 | River Ridge | 25 | |