| Date | Week | Home | Score | Away | Score | |
| 8/18/2022 | 1 | Waterloo (NC) | 42 | Pecatonica/Argyle | 0 | |
| 8/26/2022 | 2 | Pecatonica/Argyle | 14 | Dodgeville (NC) | 45 | |
| 9/2/2022 | 3 | Pecatonica/Argyle | 14 | Mineral Point | 35 | |
| 9/9/2022 | 4 | Darlington | 72 | Pecatonica/Argyle | 0 | |
| 9/16/2022 | 5 | River Ridge | 47 | Pecatonica/Argyle | 7 | |
| 9/24/2022 | 6 | Pecatonica/Argyle | 6 | Potosi/Cassville | 64 | |
| 10/1/2022 | 7 | Pecatonica/Argyle | 0 | Benton/Scales Mound IL/Shullsburg | 48 | |
| 10/7/2022 | 8 | Southwestern/East Dubuque, IL | 50 | Pecatonica/Argyle | 7 | |
| 10/14/2022 | 9 | Black Hawk/Warren, IL | 48 | Pecatonica/Argyle | 0 | |