| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Potosi/Cassville | 34 | Wauzeka-Steuben/Seneca (NC) | 6 | |
| 8/26/2022 | 2 | Ithaca (NC) | 8 | Potosi/Cassville | 36 | |
| 9/2/2022 | 3 | Potosi/Cassville | 7 | Belleville | 30 | |
| 9/9/2022 | 4 | Mineral Point | 27 | Potosi/Cassville | 34 | |
| 9/16/2022 | 5 | Benton/Scales Mound IL/Shullsburg | 12 | Potosi/Cassville | 28 | |
| 9/24/2022 | 6 | Pecatonica/Argyle | 6 | Potosi/Cassville | 64 | |
| 9/30/2022 | 7 | Potosi/Cassville | 42 | Black Hawk/Warren, IL | 18 | |
| 10/7/2022 | 8 | River Ridge | 13 | Potosi/Cassville | 27 | |
| 10/14/2022 | 9 | Potosi/Cassville | 44 | Southwestern/East Dubuque, IL | 20 | |