| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Saint Croix Central (NC) | 54 | Spencer/Columbus Catholic | 21 | |
| 8/26/2022 | 2 | Spencer/Columbus Catholic | 0 | Colby (NC) | 41 | |
| 9/2/2022 | 3 | Spencer/Columbus Catholic | 0 | Wittenberg-Birnamwood | 35 | |
| 9/9/2022 | 4 | Spencer/Columbus Catholic | 7 | Weyauwega-Fremont | 42 | |
| 9/16/2022 | 5 | Amherst | 0 | Spencer/Columbus Catholic | 1 | |
| 9/23/2022 | 6 | Nekoosa | 36 | Spencer/Columbus Catholic | 0 | |
| 9/30/2022 | 7 | Spencer/Columbus Catholic | 18 | Manawa | 20 | |
| 10/7/2022 | 8 | Spencer/Columbus Catholic | 0 | Stratford | 41 | |
| 10/14/2022 | 9 | Shiocton | 40 | Spencer/Columbus Catholic | 12 | |