| Date | Week | Home | Score | Away | Score | |
| 8/18/2022 | 1 | Milwaukee Bay View/Milw Lifelong Learning | 0 | Milwaukee King | 57 | |
| 9/2/2022 | 3 | Milwaukee Reagan | 16 | Milwaukee Bay View/Milw Lifelong Learning | 14 | |
| 9/8/2022 | 4 | Milwaukee Bay View/Milw Lifelong Learning | 6 | Milwaukee Hamilton/Audubon Tech | 43 | |
| 9/16/2022 | 5 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 25 | Milwaukee Bay View/Milw Lifelong Learning | 0 | |
| 9/22/2022 | 6 | Milwaukee Bay View/Milw Lifelong Learning | 0 | Milwaukee Riverside/Golda Meir | 42 | |
| 9/29/2022 | 7 | Milwaukee Bradley Tech/Milw Arts | 7 | Milwaukee Bay View/Milw Lifelong Learning | 28 | |
| 10/7/2022 | 8 | Milwaukee Bay View/Milw Lifelong Learning | 22 | Milwaukee Pulaski/Carmen South/Carmen SE (NC) | 36 | |
| 10/13/2022 | 9 | Milwaukee Bay View/Milw Lifelong Learning | 56 | Milwaukee North | 6 | |