| Date | Week | Home | Score | Away | Score | |
| 8/19/2022 | 1 | Milwaukee Bradley Tech/Milw Arts (NC) | 7 | Milwaukee Pulaski/Carmen South/Carmen SE | 60 | |
| 8/26/2022 | 2 | Milwaukee Pulaski/Carmen South/Carmen SE | 1 | Obama SCTE | 0 | |
| 9/1/2022 | 3 | Milwaukee Madison | 0 | Milwaukee Pulaski/Carmen South/Carmen SE | 1 | |
| 9/9/2022 | 4 | Milwaukee Pulaski/Carmen South/Carmen SE | 18 | Milwaukee Vincent/Destiny | 20 | |
| 9/15/2022 | 5 | Milwaukee North | 6 | Milwaukee Pulaski/Carmen South/Carmen SE | 50 | |
| 9/23/2022 | 6 | Milwaukee Pulaski/Carmen South/Carmen SE | 28 | Milwaukee South | 16 | |
| 9/29/2022 | 7 | Milwaukee Washington/Fuller Collegiate | 2 | Milwaukee Pulaski/Carmen South/Carmen SE | 8 | |
| 10/7/2022 | 8 | Milwaukee Bay View/Milw Lifelong Learning (NC) | 22 | Milwaukee Pulaski/Carmen South/Carmen SE | 36 | |
| 10/14/2022 | 9 | Milwaukee Pulaski/Carmen South/Carmen SE | 0 | Milwaukee King | 34 | |