| Date | Week | Home | Score | Away | Score | |
| 8/21/2021 | 1 | Pewaukee (NC) | 48 | Milwaukee Riverside/Golda Meir | 8 | |
| 8/27/2021 | 2 | Rhinelander (NC) | 50 | Milwaukee Riverside/Golda Meir | 22 | |
| 9/2/2021 | 3 | Milwaukee Riverside/Golda Meir | 1 | Milwaukee Washington/Fuller Collegiate | 0 | |
| 9/10/2021 | 4 | Milwaukee Riverside/Golda Meir | 58 | Milwaukee Bradley Tech/Milw Arts | 0 | |
| 9/16/2021 | 5 | Milwaukee Bay View/Milw Lifelong Learning | 0 | Milwaukee Riverside/Golda Meir | 1 | |
| 9/24/2021 | 6 | Milwaukee Riverside/Golda Meir | 6 | Milwaukee King | 17 | |
| 9/30/2021 | 7 | Milwaukee Marshall/Carmen NW/Milw Juneau/Milw Languages | 26 | Milwaukee Riverside/Golda Meir | 6 | |
| 10/8/2021 | 8 | Milwaukee Riverside/Golda Meir | 16 | Milwaukee Hamilton/Audubon Tech | 20 | |
| 10/14/2021 | 9 | Milwaukee Hamilton/Audubon Tech | 24 | Milwaukee Riverside/Golda Meir | 14 | |